@
Valentijn , @
caledonia and all experts pls help me interpret this results.
Hi Inester,
Methylation cycle:
You have no First Priority mutations.
You have MTHFR A1298C, so some methylfolate for that. This is only about a 20% reduction, so you probably wouldn't need a large amount, unless there was some other blocking factor.
MTRR is B12 recycling so some B12 for that. I think the K350A is one of the more minor ones, so again you probably wouldn't need that much supplementation (genetically speaking). For your COMT/VDR combo Yasko suggests all three types of B12 (hydroxy, methyl and adenosyl) with less methylcobalamin.
You have VDR Bsm which is the vitamin D receptor, so get your vit. D levels checked and supplement for that if it's low.
The BHMTs are secondary backup methylation cycle, so some lecithin for that to produce some TMG.
MAO can affect serotonin. Yasko suggests to balance the rest of the cycle first, then if you're still having mental health type problems, supplement with a sprinkle of 5htp. This would be contraindicated if you're on an SSRI/SNRI.
The ACHYs are supposed to balance themselves once the rest of the cycle is balanced.
Detox SNPs:
GSTT1 present - this affects glutathione, so it being present is good.
The CYP1B1s regulate estrogen. Mutations can cause estrogen dominance which can cause estrogen related cancers. You can eat cruciferous veggies or take DIM, IC3 or calcium d-glucarate to lower estrogen.
CYP2E1*1B +/- detoxifies nitrosamines and ethanol (acetaldehyde), so you may have trouble tolerating those.
NAT2 - the NATs detoxify petrochemicals and smoke. So don't smoke and avoid petrochemicals and smoke.
CYP3A4*1B detoxifies over 50% of all prescription medications and most steroid hormones, so you may have trouble tolerating those.
SOD2 A16V - super oxide dismutase. This affects the mitochondria and thus energy. You can do general mito support like CoQ10, ribose, carnitine, etc. or try a GliSODin formula or Biotec Extra Energy Enzymes.
The Detoxigenomics Sample Report in my signature links has a lot more info on these, including drug lists.
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Like the others are saying, in general, your SNPs aren't that bad. In that case, I would start looking to possible functional issues as a greater factor in what is causing you to be sick. For example, mercury and lead can both mess up folate and B12 functioning. Oral birth control depletes folate. Vegetarianism can deplete B12 if not properly supplemented. Antacids can deplete B12. Various other medications can deplete folate, B12 and various other things. Gut issues can impede vitamin and mineral absorption. Toxic exposures can deplete glutathione. etc. etc. etc. etc.
A Nutreval test might be invaluable in pointing you in the right direction.
