Hi, i wanted to ask if the persons on fredd's protocol or anyway on a methylation protocol can tell e the dosage of methylb12, methylfolate, carnitine fumarate, adenosilcobalamine they starded with and the dosage they then have stabilized on just to have an idea.
I bought all the supplements and now i really don't know how to procede..i mean i'll start one at time starting from methyl and adenosil then i will add methylfolate and carnitine but i don't know the proprotion among these supplements.
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Freddd can u advice me? in your opinion how much of each supplement i should start with? and ther eis a proportion among b12-methylfolate and fumarate to respect?
Hi Josh,
I would suggest starting with an all around selection of vitamins and minerals which will be needed in greater quantity as soon as your body starts healing. Things like, A, low-dose b-complex suitable for twice a day without folic acid or CyCbl, C, D, E, zinc, magnesium, calcium, omega3 oils, lecithin (or variant). There are many opinions as to which brands or types may be most effective.
Then the question comes up do you have anxiety. If you have anxiety and hyper responses, one needs to start with crumbs of AdoCbl and MeCbl, of the 5 star brands.
If not having anxiety, then a 1mg Enzymatic Therapy or 1/4 of Country Life Methyl B12 5mg, 1/4 capsule or tablet of Anabol Naturals AdoCbl and 1/4 of an 800mcg Metafolin 4 times a day is a good starting place for many. There is often a brightening of everything neurological as the nerves start working better than they have in years. Pains intensify, things look brighter (dimming of vision is a b12 deficiency symptom), sensations that have been ignored for years become new and obvious again. Often there is a significant increase in energy as the AdoCbl gets into the mitochondria. If a healing startup occurs then often on about the third day a person starts to feel really sick. This is typically a combination of two induced deficiencies, low potassium and donut hole paradoxical folate deficiency. It is dangerous to ignore the low potassium and very unpleasant to ignore the low folate. These can be taken to a balance point were those symptoms go away. The low potassium symptoms can go away in hours and also return in hours without another dose. A lot of people find that the need for potassium can jump up from 1200 to over 2000mg a day and adjustments need to be made as things progress. The low folate symptoms can start being relieved in hours and a person may end up needing anywhere from maybe 1600 to 30,000 mcg a day depending upon a whole lot of factors. Here is a list of the more common symptoms. Many people might have several from both varieties. Which exact ones though vary tremendously from person to person.
After a comfortable balance is reached and the brightening has become normal, then carnitine, usually L-carnitine fumarate (90%) but for some ALCAR (10%) can be titrated. Again, if a person has anxiety microtitration would be suggested, starting at maybe 100mcg per day divided in 3 doses with the Jarrow liquid carnitine. Otherwise a 1/8 of a capsule might be started with. LCF can be very energizing and it is the item that has a very direct dose response curve and is most easily controlled. any people find they do better with several doses without food a day instead of one larger one in the morning. Bodies differ.
Version 1.2 12/08/2013
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).
There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.
IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,
Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness
Abnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressure
Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.
Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.
Old symptoms returning
Edema
Angular Cheilitis, Canker sores,
Skin rashes, increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips,
Increased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,
Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Increase irritability, Heart palpitations,
Longer term, very serious
Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily
Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.