Norwegian rituximab study to start 2014

[Firestormm]

Yeah I must admit - and without time to look again at the published paper - but I thought it was Fukuda and CCC first time. Might be wrong, but I didn't think it was only Fukuda because that would have raised more concerns among the patients...

@Bob can you remember off the top of your head? Thanks

 

[Ninan]

It was only Fukada. But later they found that almost all patients (except maybe two, not sure) fitted CCC.

Now since Rituximab probably doesn't have much effect on depression I guess using CCC will increase the number of responding patients rather than decrease it. They have seen better results in later studies. This could be due to using better criteria.

 

[Ninan]

"The inclusion criteria were: a diagnosis of CFS by a neurologist, according to the Fukuda 1994 criteria [5], age 18–65 years, and written informed consent. Exclusion criteria were: fatigue not fulfilling CFS criteria, previous malignant disease (except basal cell carcinoma and cervical dysplasia), previous long-term immunosuppressive treatment, previous Rituximab treatment, endogenous depression, lack of ability to adhere to protocol, or evidence of on-going infection."

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026358

 

[Firestormm]

Thanks @Ninan I am flicking back and forth between editing an article - and my brain cell went on strike

 

[Ninan]

Thanks @Ninan I am flicking back and forth between editing an article - and my brain cell went on strike

Yeah, I know it sucks to have only one.

 

[user9876]

It was only Fukada. But later they found that almost all patients (except maybe two, not sure) fitted CCC.

Now since Rituximab probably doesn't have much effect on depression I guess using CCC will increase the number of responding patients rather than decrease it. They have seen better results in later studies. This could be due to using better criteria.

I thought that they had a placebo response from someone fulfilling the Fukada definition but not the CCC one.

 

[Ninan]

I thought that they had a placebo response from someone fulfilling the Fukada definition but not the CCC one.

That's possible. I don't remember.

 

[Valentijn]

I thought that they had a placebo response from someone fulfilling the Fukada definition but not the CCC one.

That's what I recall as well ... that the "cured" placebo patient was not CCC.

 

[Ninan]

That's what I recall as well ... that the "cured" placebo patient was not CCC.

Maybe they found the one with the "bodily distress syndrome". Escaped from Denmark.

 

[aimossy]

Its been a while I am hoping their last paper will be published within a few months from now.

Edit. actually just realised it wasn't long since I looked here.....completely lost with time frames at the moment.