Critterina
Senior Member
- Messages
- 1,238
- Location
- Arizona, USA
Thanks, Valentijn.
Well, that's surprising to me based on my reaction when I added folinic acid to my regimen, but I made a lot of changes at once, so perhaps I need to isolate the change and try again. Hmmm, how would it complicate things for an MTHFR C677T mutation then, I wonder? If it's not depriving it of substrate, (which would affect more than C677T people), what could it be doing?The SHMT is a bit of a "?", but since it has been studied and the increased risk only shown when combined with another SNP, it's pretty unlikely that it does anything on its own. Plus it is a "synonymous substitution", which means the + version doesn't result in a structural change to the protein created by the gene - which means it would be very hard for this SNP to have much of an impact.
Thanks. That was a good one, but that wasn't it. Maybe I confused or conflated something.I'm not sure about the COMT discussion. Maybe you mean http://forums.phoenixrising.me/index.php?threads/interesting-comt-variations.24672/ where I have other COMT variations listed? It's possible that the additional COMT variations are having an additional impact to the ones listed by Yasko and GeneticGenie.