Possibly, but that's not what this study is claiming. They're saying that certain SNPs are more common in ME/CFS patients, suggesting that those SNPs (and/or genes) contribute to developing ME/CFS.Might I suggest that rare mutations in genes such as GRIK2 and COMT are not directly related to ME/CFS (i.e. direct causation - although they may contribute to a range of 'stressors') but may help determine the range of symptoms an individual develops after onset?