I know you want to talk symptoms but I want to share my newbie Methyl-B12 experience + my 'oldbie' need for Lithium. (the mineral supplememt, not the drug)
2 days ago I started Methyl-B12. Just 1500mcg to get started. I felt instant bliss! (I have a sensitive body, I register a lot which is a nuisance as I get overwhelmed quickly but it also helps me with finding what foods and supplements help. But still, I could not believe this. But as I have repeated this experience without fault four times now I'm getting hopeful)
Minutes after ingesting a calm rises in me. It feels like the instant bliss progesteron (NPC) gives me but a little different from that. NPC is more like a wave that washes over me, something from outside is welcomed. With the m-B12 it seems to come from within. Today again, but after a while it weaned and my brain got excited (I'm also detoxing Copper at the moment while I bring my Zinc levels up so that may explain it. Or detoxing prompted by methylation-cycle). As I had read that this MTR/MTRR combination I've got going on really cranks up the need for M-B12, even to 5000mcg per day, I took another pil.
Again: bliss and calm. Both in my body and in my head.
Really....I never... I enjoyed it tremendously, i felt like my old self. But I was a good student and I had a lie down to aid my body and adrenals. I also resisted taking another pill when the effect wore off after a couple of hours and I returned to being exhausted. I don't know exactly what I'm messing with yet so best proceed with caution. However: the second half of the day I forgot to take my hydrocortison (hc) and I have not missed it. This is huge. My stomach acid is still ok, my bowels have their motility, bile is flowing, no stress from noise. This is not normal without hc.
Now I'm waiting for the other shoe to drop. Major detox symptoms perhaps. But I have hope I won't have major detox: in the last few years I've been detoxing a lot by not being in Fight or Flight and by eating clean (I naturally gravitated towards a low thiol diet) and this Spring my body felt souple. Still tired but not burdened anymore. Which is why I took on the Zinc/Copper challenge. I doubt there's much left to detox.
My plan was to do this Copper detox. Then slowly wean off the hc. Then get tested for Addison's disease by endocrinologists. Because souple body or not, I hit a plateau and am not getting beyond 40% life activity (leave the house once a week, have 4 spoons a day). So the cause must be a physical fault and I was thinking adrenals. Then Gestalt put the idea of 23andme in my head. And you built GeneticGenie for the whole world to use.
About Lithium.
Years ago a naturopath discovered my body screamed for lithium. I've been supplementing it ever since, from Biotics. Not knowing anything apart from that it felt rigth. And I'm getting symptoms if I don't: depression, despair, a hunger for a meaningfull life and fame plus utter despair from knowing I won't, PMS, suicidal.
Just the fact that these symptoms disappear when I take this mineral (or when I stay away from vanillin or birth control hormones or soja) tells me those moods are not me. It is messed up brain chemistry.
Over at AutismWeb I've just read that lithium is very important especially in homozygous MTR A2756G and when supplementing m-B12. My body seems to echo this. What is your experience?
(sorry, need to do a Pippi now: "Utter despair? You feel utter despair?! I'm sure you meant to write "otter despair". Because when otters despair it's messed up brain chemistry for sure!
Unless you've got too much estrogen... then it's udder despair. Either way: it's not you. It's your chemicals.")