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I am researching optimal means of chelation for a friend, so any thoughts of this issue would be greatly appreciated. I am now worried whether or not she should stop her supplementary 400mcg folate and 1 gram vitamin C.
Abstract:
"Ingestion of megadoses of certain vitamins appears to influence the in vivo methylation of mercuric chloride in guinea pigs. The addition of megadoses of vitamin B12 fed either singularly or in combination with folic acid resulted in increased methylmercury concentrations in the liver. Moreover, percent methylmercury levels were significantly increased with B12 treatment in the liver (B12 only and B12/folic acid) and brain (B12/vitamin C). Incorporation of high levels of folic acid into the dietary regime also increased the methylmercury concentration particularly in the liver and hair tissues. The addition of vitamin C in the diet, particularly in combination with B12 (brain) or folic acid (muscle) resulted in increased methylmercury levels in these tissues and percent methylmercury values with B12 in the muscle and brain tissue."
Source: http://www.ncbi.nlm.nih.gov/pubmed/2388525
Why would increasing the function of the methylation lead to mobilization into the brain? This system helps us EXCRETE toxins in our urine and feces. Vitamin C is also a precursor to glutathione, so that should have also helped with the detoxification process, instead of leading to the opposite reaction. Was it just the fact that megadoses were used? Still though, it is very troubling...
Abstract:
"Ingestion of megadoses of certain vitamins appears to influence the in vivo methylation of mercuric chloride in guinea pigs. The addition of megadoses of vitamin B12 fed either singularly or in combination with folic acid resulted in increased methylmercury concentrations in the liver. Moreover, percent methylmercury levels were significantly increased with B12 treatment in the liver (B12 only and B12/folic acid) and brain (B12/vitamin C). Incorporation of high levels of folic acid into the dietary regime also increased the methylmercury concentration particularly in the liver and hair tissues. The addition of vitamin C in the diet, particularly in combination with B12 (brain) or folic acid (muscle) resulted in increased methylmercury levels in these tissues and percent methylmercury values with B12 in the muscle and brain tissue."
Source: http://www.ncbi.nlm.nih.gov/pubmed/2388525
Why would increasing the function of the methylation lead to mobilization into the brain? This system helps us EXCRETE toxins in our urine and feces. Vitamin C is also a precursor to glutathione, so that should have also helped with the detoxification process, instead of leading to the opposite reaction. Was it just the fact that megadoses were used? Still though, it is very troubling...