- Messages
- 2,573
- Location
- US
I am CC.
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
I've left a note in your inbox@Valentijn
much as I would like nay love to understand any of this I can't
but if you tell me where to look I will try to find it. also you can have a copy of my results with pleasure.
CC here. Then again, I was never diagnosed with ME/CFS.
It should be compatible. How is it malfunctioning?@Valentijn I tried to use your rare snp analyser but I couldn't get it to work once I downloaded it. I use a Mac. Could that be the problem? Is it compatible with a Mac?
I sent you a pm. Thanks for the work you are doing.
I finally figured out how to do the math - it uses the hardy-weinberg equation, which basically says that the prevalence of the rarer homozygous genotype will be the prevalence of the minor allele squared. So for rs952061 with a prevalence of 10.3% that will be .103 x .103 = 1.06% prevalence.On openSNP 22% have the CT version. No one in our family has ME/CFS but my husband and one son are CT for this SNP, I don't know if it is as rare to be hetero on this one as you think, but it looks like the double mutation is very rare.
I think that is in range of the openSNP results. I think they are drawing from a fairly small database. It's interesting to note that both my husband and the son who are hetero for this have a tendency towards slight depression. (This is not the son who has depression from gut problems, he was normal before his gut dysbiosis.) My daughter and I are not prone to depression and we don't have it.I finally figured out how to do the math - it uses the hardy-weinberg equation, which basically says that the prevalence of the rarer homozygous genotype will be the prevalence of the minor allele squared. So for rs952061 with a prevalence of 10.3% that will be .103 x .103 = 1.06% prevalence.
For homozygous, it's 2 x the minor allele prevalence x the major allele prevalence. So the heterozygous prevalence should be 2 x .103 x .897 = 18.5%.
About 1088 people for that sample.I think that is in range of the openSNP results. I think they are drawing from a fairly small database.
It's a myth which has never been substantiated. While many papers do reach that conclusion, or make that assumption, they're are based on mental health questionnaires where physical symptoms are taken as sign of a mood disorder. I doubt depression in ME/CFS patients is any more prevalent than it is in patients with other chronic debilitating illnesses.I have no idea what it is associated with! It's just that I was thinking that people here often had depression but I don't really know that much about it. It just popped into my head!