Hi Joe,
COMBUNATIONS are the key. Start on AdoCbl AND MeCbl (crumbs of a pill are ok, hold under lip). Start the methylfolate with them. It has a short halflife so a quarter pill each 6 hours could work better and help level it out. Bounding around like that will make things worse and worse. You responded to the MeCbl. That is an important CLUE. With some careful titrating and understanding what is a signal of healing turning on versus a side effect. These signals are often induce deficiencies of many different kinds. That is why one takes a b-complex, and basic minerals and vitamins etc or it is like shooting an elephant with a BB gun; it's a struggle all the time then and healing never really works when it is stopped and started all over the place. Be care of the conclusions you jump to. Each one puts you farter away from being able to heal. When one starts those first 34 on about the third day one often needs more potassium and folate, if the symptoms as are listed.
WHEN TREATED
All of these are flags indicating healing is occurring. Minimizing nervous system response reduces or stops healing, especially of the nervous system. Minimizing ATP response prevents normalization of biochemistry.
1 - Low potassium, almost everybody when healing starts. – often called “detox”
2 - Low folate symptoms even with small doses of Metafolin – often called “detox”
3 - Nervous system activation, everything is perceived as more intense – often called “detox”
4 – ATP activation, everything is more energetic and intense – often called “detox”
Whatever distinctions are made, a key characteristic is that symptoms, once well developed, of these syndromes will include multiple tissue types, multiple systems. To the casual observer they appear to be not connected. After all what do blood abnormalities, eczema, irritable bowel syndrome, daily nausea and vomiting, severe fatigue, muscle atrophy, asthma, hypersensitive nervous system responses, muscle pains, MCS, mood and personality changes, widespread body pain, peripheral neuropathy, poly neuropathies, burning bladder, poor immune response, FMS, CFS, autoimmune response, raspy voice, unable to focus eyes, faded vision, multi sensory hallucinations and many others have in common? They all share a common set of nutritional deficiency causes. Some will argue that these are not “absolute deficiencies” but rather “functional deficiencies”. For treatment purposes that doesn’t matter unless one is trying to restrict access to treatment (insurance won’t cover)
The more severely affected a person is the harder hitting the vitamins are when started. There are several initial responses that may occur. In the popular terminology most of them are lumped together under the term “DETOX” reaction or response. These responses may start in minutes to days depending up many circumstances.
The supplements being considered here are methylcobalamin, adenosylcobalamin, hydroxycobalamin, cyanocobalamin, folic acid, folinic acid, Metafolin-methylfolate, SAM-e, L-carnitine, glutathione, NAC (N-acetyl cysteine), Cerefolin-NAC, Whey, Metanx, Deplin.
More rarely Vitamins D – A - C, magnesium, zinc, p5p
Glutathione, NAC, Cerefolin-NAC, whey are all glutathione or glutathione precursors. The NAC typically overpowers the Cerefolin completely.
Metafolin, methylfolate, Deplin are all methylfolate
Metanx is Metafolin, methylb12 and P5P
B12 forms, in order of effectiveness and likelihood of causing the responses listed here are methylcbl, adenosylcbl, hydroxycbl, cyanocbl
Typically several of these symptoms will appear suddenly with more appearing and worsening over time if corrections are not made. While these groups of symptoms are called “detox” by some alternative practitioners and many people otherwise knowledgeable about vitamins and supplements, depending upon what theories they are operating under, use this term. Typically they are working on a “toxin” theory of CFS/FMS/ME/MCS etc and that these vitamins and supplements mobilize the toxins which then cause all sorts of symptoms in the groups listed. As the “translations” are made it is clear that actual “detox” if it exists, has nothing to do with these symptoms and they can be dangerous to ignore. If it is “detox” in an actual sense, then it is in what is left after these other things are accounted for and/or corrected, perhaps 5-10% of the total initial number. Also, co-morbidities often show up in this way..
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with cyanocobalamin it is very common with methylb12 and adensosylb12 and less so with hydroxycobalamin..
IBS – Steady constipation , Nausea, Vomiting, Paralyzed Ileum, Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness, Abnormal heart rhythms (dysrhythmias), Increased pulse rate, Increased blood pressure, Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract, increased hypersensitive responses , Skin rashes, Increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips, Angular Cheilitis, Canker sores, Coated tongue, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, Increase irritability, Loss of reflexes, Fevers, Old symptoms returning, Heart palpitations, Bleeding easily.
Group 4 - Hydroxycbl onset, degraded methylcbl onset, methylcbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
Group 3 symptoms, induced paradoxical folate deficiency or insufficiency are corrected quickly with titrated doses of Metafolin, methylb12 and adenosylb12. If glutathione (precursors) are the cause then larger doses of Metafolin, 7.5-15mg,or maybe more are needed. Different tissues are affected at different levels of methylfolate, it comes or goes in stages. Very strong dose proportionate characteristics are present. Serum folate levels may be high or even very high despite Metafolin responsive deficiency/insufficiency symptoms.
Group 1 symptoms respond readily to potassium. The symptoms and response to potassium may occur at a serum level of 4.3 or less.
INDUCED HYPOKALEMIA AND FOLATE INSUFFICIENCY DECISION TREE
IF taking Glutathione, NAC, Cerefolin-NAC, whey, all glutathione or glutathione precursors
AND often sudden onset of several group 3 symptoms (“Detox”) maybe in a sequence, ie pain and inflammation the first day, cheilitis occurs on day 2-3 and IBS on day 5-6, plus any group 2 symptoms. Symptoms increase for weeks or months and can vary from mild to extreme.
THEN Induced Paradoxical Folate Deficiency onset. B12 deficiencies follow in a week for methylb12 deficiency symptoms and several weeks for adenosylb12 deficiency symptoms. None of the other supplements can overcome the effects of glutathione or NAC.
ELSE - all other conditions
IF injecting b12
AND itchy bumps and acne type lesions appear mostly on scalp and face but not exclusive
THEN B12 was hydroxycbl OR photolytically deteriorated methylcbl OR cyanocbl, Lesions can be reversed in days with methylcbl injections not exposed to light at all.
IF starting or adding methylb12, adenposylb12 or hydroxycbl, AND OR Metafolin (perhaps 80%)
AND the approximately 3rd day or later onset of symptoms (“Detox”) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden widespread healing onset. This usually occurs as soon as methylation therapy starts widespread healing process by allowing DNA replications with methylb12 and methylfolate.
IF adding adenosylcobalamin AND OR L-carnitine fumarate AND OR SAM-e to program (perhaps 50%)
AND the approximately 3rd day or later onset of symptoms (“Detox”) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden healing and /or muscle growth. This usually occurs when the person has experienced muscle shrinkage perhaps from decades of inactivity, as soon as these supplements step up mitochondria functioning.
IF adding or increasing any of Vitamins D, A, E, or C, magnesium, zinc (perhaps 10%)
AND on the approximately 3rd day or later onset of symptoms (“Detox”) from Group 1 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (“Detox”) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folic acid is the most oxidized form of folate that anybody can use. In some unknown percentage of people who appear unable to convert folic acid adequately to methylfolate the accumulating unconverted folic acid can actually block the methylfolate.
IF starting or increasing folinic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (“Detox”) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is a less oxidized form of folate than folic acid.. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF an increase in dietary vegetable folate, “green drinks”, a garden feast
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (“Detox”) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid AND OR starting or increasing folinic acid AND OR an increase in dietary vegetable folate
AND the approximately 3rd day or later onset of symptoms (“Detox”) from Group 1 and/or group2
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (“Detox”) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency AND this can be the onset of Hypokalemia triggered by sudden healing
IF starting or Methylfolate – Metafolin starting low and titrating
AND the approximately 3rd day or later onset of symptoms (“Detox”) from Group 1 and/or group2
AND OR usually takes a number of days to accumulate to a level leading to onset of symptoms (“Detox”) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency, a “donut hole” deficiency. The effects of folate deficiency/insufficiency comes in layers. Several tissue groups can be healing at the same time as other tissue groups are deteriorating. IBS and angular cheilitis can be worsening at the same time as muscles are healing or growing. There is a dose of Metafolin that can start more tissue formation than the same dose can sustain causing a Paradoxical Folate Insufficiency at the same time. In some people at least as they increase Metafolin the need for potassium increases approximately proportionately. The donut hole can be closed with total daily doses of Metafolin of about 15mg for many people.