I finally received my 23andme results yesterday and ran the methylation report and detox report on geneticgenie with the raw data.
One thing that really bothers me is the difference between 23andme and genova detoxigenomic result on my SOD2 gene. On the 23andme result it shows as -/- while detoxigenomics is +/+. Who's right, who's wrong?
Anyway, here are my results. Hope to hear some recommendations.
23andme + geneticgenie methylation profile
Gene & Variation rsID Alleles Result
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 GG -/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 AG +/-
23andme Genova detoxigenomics
Gene & Variation rsID Alleles Result Result
CYP1A1*2C A4889G rs1048943 TT -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A1 m3 T3205C rs4986883 TT -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A1 C2453A rs1799814 GG -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A2 164A>C rs762551 AC +/- Not included in genova detoxigenomics
CYP1B1 L432V rs1056836 GG +/+ NO polymorphims on CYP1B1 / not sure which variation is tested
CYP1B1 N453S rs1800440 TT -/- NO polymorphims on CYP1B1 / not sure which variation is tested
CYP1B1 R48G rs10012 CG +/- NO polymorphims on CYP1B1 / not sure which variation is tested
CYP2A6*2 1799T>A rs1801272 AA -/- NO polymorphims on CYP2A6 / not sure which variation is tested
CYP2A6*20 rs28399444 II -/- NO polymorphims on CYP2A6 / not sure which variation is tested
CYP2C9*2 C430T rs1799853 CT +/- Polymorphism detected for CYP2C9 / not sure which variation is tested
CYP2C9*3 A1075C rs1057910 AA -/- Polymorphism detected for CYP2C9 / not sure which variation is tested
CYP2C19*17 rs12248560 CC -/- NO polymorphims on CYP2C19 / not sure which variation is tested
CYP2D6 S486T rs1135840 CG +/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2D6 100C>T rs1065852 AG +/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2D6 2850C>T rs16947 GG -/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2E1*1B 9896C>G rs2070676 CC -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP2E1*1B 10023G>A rs55897648 GG -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP2E1*4 4768G>A rs6413419 GG -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP3A4*1B rs2740574 TT -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*2 S222P rs55785340 AA -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*3 M445T rs4986910 AA -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*16 T185S rs12721627 GG -/- NO polymorphims on CYP3A4 / not sure which variation is tested
GSTP1 I105V rs1695 AG +/- +/-
GSTP1 A114V rs1138272 CT +/- +/-
SOD2 A16V rs4880 AA -/- +/+
NAT1 R187Q rs4986782 GG -/- -/-
NAT1 R64W rs1805158 CC -/- -/-
NAT2 I114T rs1801280 CT +/- +/-
NAT2 R197Q rs1799930 AG +/- +/-
NAT2 G286E rs1799931 GG -/- -/-
NAT2 R64Q rs1801279 GG -/- -/-
NAT2 K268R rs1208 AG +/- +/-
Gene Result Result
GSTT1 Absent* maybe absent
One thing that really bothers me is the difference between 23andme and genova detoxigenomic result on my SOD2 gene. On the 23andme result it shows as -/- while detoxigenomics is +/+. Who's right, who's wrong?
Anyway, here are my results. Hope to hear some recommendations.
23andme + geneticgenie methylation profile
Gene & Variation rsID Alleles Result
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 GG -/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 AG +/-
23andme Genova detoxigenomics
Gene & Variation rsID Alleles Result Result
CYP1A1*2C A4889G rs1048943 TT -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A1 m3 T3205C rs4986883 TT -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A1 C2453A rs1799814 GG -/- NO polymorphims on CYP1A1 / not sure which variation is tested
CYP1A2 164A>C rs762551 AC +/- Not included in genova detoxigenomics
CYP1B1 L432V rs1056836 GG +/+ NO polymorphims on CYP1B1 / not sure which variation is tested
CYP1B1 N453S rs1800440 TT -/- NO polymorphims on CYP1B1 / not sure which variation is tested
CYP1B1 R48G rs10012 CG +/- NO polymorphims on CYP1B1 / not sure which variation is tested
CYP2A6*2 1799T>A rs1801272 AA -/- NO polymorphims on CYP2A6 / not sure which variation is tested
CYP2A6*20 rs28399444 II -/- NO polymorphims on CYP2A6 / not sure which variation is tested
CYP2C9*2 C430T rs1799853 CT +/- Polymorphism detected for CYP2C9 / not sure which variation is tested
CYP2C9*3 A1075C rs1057910 AA -/- Polymorphism detected for CYP2C9 / not sure which variation is tested
CYP2C19*17 rs12248560 CC -/- NO polymorphims on CYP2C19 / not sure which variation is tested
CYP2D6 S486T rs1135840 CG +/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2D6 100C>T rs1065852 AG +/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2D6 2850C>T rs16947 GG -/- NO polymorphims on CYP2D6 / not sure which variation is tested
CYP2E1*1B 9896C>G rs2070676 CC -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP2E1*1B 10023G>A rs55897648 GG -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP2E1*4 4768G>A rs6413419 GG -/- Polymorphism detected for CYP2E1 / not sure which variation is tested
CYP3A4*1B rs2740574 TT -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*2 S222P rs55785340 AA -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*3 M445T rs4986910 AA -/- NO polymorphims on CYP3A4 / not sure which variation is tested
CYP3A4*16 T185S rs12721627 GG -/- NO polymorphims on CYP3A4 / not sure which variation is tested
GSTP1 I105V rs1695 AG +/- +/-
GSTP1 A114V rs1138272 CT +/- +/-
SOD2 A16V rs4880 AA -/- +/+
NAT1 R187Q rs4986782 GG -/- -/-
NAT1 R64W rs1805158 CC -/- -/-
NAT2 I114T rs1801280 CT +/- +/-
NAT2 R197Q rs1799930 AG +/- +/-
NAT2 G286E rs1799931 GG -/- -/-
NAT2 R64Q rs1801279 GG -/- -/-
NAT2 K268R rs1208 AG +/- +/-
Gene Result Result
GSTT1 Absent* maybe absent