Help interpreting my results

[Dylan]

Hi,

I was hoping one of the enlightened folks on here could also help me interpret these results:

Gene & Variation rsID Alleles Result
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 GG -/-
MAO A R297R rs6323 G -/-
ACAT1-02 rs3741049 AG +/-
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GG +/+
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AA +/+
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 GG -/-

 

[caledonia]

Hi,

I was hoping one of the enlightened folks on here could also help me interpret these results:

Gene & Variation rsID Alleles Result
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 GG -/-
ACAT1-02 rs3741049 AG +/-
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GG +/+
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
CBS C699T rs234706 AA +/+

Hi Dylan,

You have two First Priority mutations which are ACAT and CBS. ACAT is one of the "leaky gut genes" and people with this can have worse gut problems. So if this sounds like you, you'll need to test and treat your gut first, while taking supps for ACAT. Yasko has an all in one ACAT/BHMT supp that would be appropriate for you, but it's kind of expensive. The main supp for ACAT is bile salts, so maybe you can get away with just taking that. I don't really know for sure.

The next one is CBS. You have two mutations on the major gene. You need to see if this gene is expressed. One way is by symptoms. If you're getting a stress/anxiety reaction when starting methyl supps, this is probably the culprit. Another way is by testing. If ammonia and sulfur is high, this is another sign. If you use the urine sulfate strips only, as a poor man's test, the sulfur should be consistently high, not go up and down.

The Heartfixer page has a good CBS protocol which I've used successfully, except for I used the Free Thiol diet and didn't take any of Yasko's RNA supps.

With MTR and a couple of MTRR's you have the B12 double whammy where B12 intake and recycling are both affected, so you will likely need some B12 supplementation for that. For your COMT/VDR combo, which unfortunately looks like the worst one, Yasko suggests mostly hydroxycobalamin. So that means methylcobalamin and adenosylcobalamin could produce mood swings.

You have MTHFR A1298C, so some methylfolate for that.

You have all the BHMTs, which is the secondary backup methylation pathway, so some TMG and phosphatidyl choline for that.

Then finally, VDR Bsm is the Vitamin D Receptor, so test to see if vitamin D is low and if so, supplement for that.

I have links to the various things I mentioned in my signature.

 

[Valentijn]

COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
VDR Bsm rs1544410 TT +/+
ACAT1-02 rs3741049 AG +/-
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GG +/+
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
CBS C699T rs234706 AA +/+

I've crossed out the SNPs which have no research at all indicating that they are ever problematic.

MTHFR A1298C typically can't cause problems on its own, but there might be a very mild methylfolate problem. A normal dose of methylfolate would be sufficient.

MTR A2756G combined with MTRR A66G can indicate a big problem creating methionine. Supplementing B12 can help with that. Due to having the slow versions of VDR and COMT, you might tolerate hydroxoB12 better than methylB12, especially if trying a high dose.

BHMT-08 might result in elevated homocysteine, which can be helped with B6.

SUMMARY:
A B-complex vitamin could be helpful, with active methylfolate (not folic acid) and B6. Some amount of B12 is probably needed, and while methylB12 might be tolerated in low doses, hydroxoB12 is probably the safer form if you want to try a higher dose.

 

[Dylan]

caledonia, Valentjin - thanks for the info!

I have had a problem with methyl supps in the past. SAMe gives me a speedy wired feeling. High doses of methyl B12 would give me a lot of anxiety randomly. Given my particular gene expression should I go with folic acid or would methylfolate but unlikely to cause the same type of thing?