Thanks so much for your interpretation of things Critterina!
I tried about a month ago to start mixed b vitamins, methyl B12, ad-B12, and TMG at the same time. I got quite a lot of anxiety with it and stopped everything deciding to wait for my 23andme results. Perhaps it was the TMG causing the anxiety? Or maybe just too much of everything at once?
Hi everyone;
Just got my 23andme data and would love some advice on how to proceed. I am fighting new onset severe depression and anxiety along with severe fatigue.
I would be so greatful for any guidance. Here is the methylation data. I will post the detox data on a new thread. Thank you!!!
COMT V158M GG -/-
COMT H62H CC -/-
COMT P199P GG -/-
VDR Bsm CT +/-
VDR Taq AG +/-
MAO A R297R TT +/+
ACAT1-02 AG +/-
MTHFR C677T GG -/-
MTHFR 03 P39P GG -/-
MTHFR A1298C GT +/-
MTR A2756G AA -/-
MTRR A66G AG +/-
MTRR H595Y CC -/-
MTRR K350A AA -/-
MTRR R415T CC -/-
MTRR A664A GG -/-
BHMT-02 CT +/-
BHMT-04 AC +/-
BHMT-08 CT +/-
AHCY-01 TT -/-
AHCY-02 AA -/-
AHCY-19 TT -/-
CBS C699T GG -/-
CBS A360A AA +/+
CBS N212N GG -/-
SHMT1 C1420T GG
-/-
It looks like you're going to have to jump through several hoops before you can tolerate methylation.
You have two First Priority mutations which are ACAT and CBS. ACAT is one of the leaky gut SNPs, i.e., people with this SNP can have more gut problems, and if they do, they need to treat the SNP while treating the gut problems to be successful. If you have leaky gut and start methyl supps you can create a deficiency of magnesium and/or potassium, as the mag/potass will be leaking out, yet you're creating a higher demand for it. You can try supplementing to compensate, but I ran into a problem where I needed more than I could possibly supplement. I had to stop methyl supps and additionally take nicotinic acid to shut down methylation as the situation was getting dangerous. There are other reasons to treat the gut first too, such as problems absorbing supps. The best way to treat the gut seems to be with a 4R gut rebuilding program.
You can get a stress/anxiety reaction if you start taking methyl supps and CBS is expressed. CBS A360A is the minor one, but you have a double mutation and you also have all the BHMTs which can add to CBS. So it would be good to check sulfur and ammonia levels and see if they're consistently high. Or to save money, you can just check sulfur levels with urine sulfate strips.
For MTHFR A1298C, some methylfolate. You only have one B12 mutation, which is MTRR. That one is B12 recycling. Maybe a bit of B12 for that, but not a definite thing. If you do take B12, for your COMT/VDR combo, Yasko suggests all three types (hydroxy, adenosyl, and methyl), but with less methyl.
You have all the BHMTs, so some TMG for that. I have the same mutations, but did get overstimulated on a small amount (I think like 50 mg, while 25mg was ok), so you have to be careful.
I had trouble with ALA detoxing too many metals. My metal detox symptoms are more like flu-like aching and fatigue, but there are a wide range of symptoms from mercury including mental ones. I wasn't doing a Cutler flush, but am considering that in the future after I'm ready for it.
When you work on the gut, you will get rid of some metals as bad gut bugs hold onto metals. When you do methylation, that will also cause metal detox and is a reason to keep it low and slow. I had problems with that when I added B12 to folate. I had to limit the amount of B12 to around 55mg.
I also did metal detox (not Cutler) several years prior to working on methylation, but I had to go extremely low and slow to tolerate it, although I was successful. In general though, knowing what I know now, I would get my methylation/detox pathways working better before attempting a Cutler protocol.
I went the route of waiting until my fillings needed replacing, vs. having them taken out right away. It all depends on your situation as to which way is the best.
By the way, mercury and lead can gum up the works at the MTHFR/MTR junction, even if you don't have bad SNPs. But I think your SNPs are similar enough to others on here, that you might have problems even without the mercury. Although, the mercury would certainly add to it.