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Genetic (SNP) Influence onThyroid Function tests

roxie60

roxie60

Senior Member
Messages
1,791
Location
Central Illinois, USA
Has anyone made progress identifying SNPs that can affect thryroid function tests? If o please post the gene, SNPs and risk alelles if you know them. I found this study that has attempted to determine the impact of some SNPs on thyroid tests which I find interesting, did not think that our genes might affect test results.

This thread can be a collection point for those interested in collecting SNP info as it relates to thyroid, or anything HPA axis/ endo related. My curiosity is due to the fact that for so many years my tests rarely seem to show anything of diagnostic value so I am starting to wonder if my genes maybe affecting th test results.

9781441914842-c2.pdf
 
V

Valentijn

Senior Member
Messages
15,786
roxie60 said:
Has anyone made progress identifying SNPs that can affect thryroid function tests?
Click to expand...
Not yet. But my sexy new rare allele program did show that I'm homozygous for a very rare allele which causes a missense mutation at rs10776792 on the TSHB gene (thyroid stimulating hormone) :cool:

No research into that one, unfortunately. My TSH tested at pretty normal levels: 2.250 with a reference range of 0.4 - 4.0. However, sometimes levels can be normal, if the substituted amino acid is not extra heat-sensitive, while the protein is still not functioning properly.
 
roxie60

roxie60

Senior Member
Messages
1,791
Location
Central Illinois, USA
Valentijn said:
Not yet. But my sexy new rare allele program did show that I'm homozygous for a very rare allele which causes a missense mutation at rs10776792 on the TSHB gene (thyroid stimulating hormone) :cool:

No research into that one, unfortunately. My TSH tested at pretty normal levels: 2.250 with a reference range of 0.4 - 4.0. However, sometimes levels can be normal, if the substituted amino acid is not extra heat-sensitive, while the protein is still not functioning properly.
Click to expand...

What is the rare/risk alelle for this SNP? Some research suggests TSH over 2.0 can leave a person feeling poorly.
 
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