Instead of "risk", as used thus far in other methylation lists, I'm marking the slower versions. The reason for this is because slow and fast COMT genes each have different medical risks, but for the purposes of methylation, it's the slow versions which can make things trickier, as the slow versions may result in reduced tolerance of methyl groups in supplements.
"Implied" slow alleles are based on studies where novelty seeking is associated the other allele, as novelty seeking has been associated with up-regulation. I'm not as confident in those sorts of studies, as they're basically making a lot of assumptions based on questionnaires and interpretations of behavior. Two haplotypes are listed at the end. These are only relevant when all of the alleles are present.
SNP names are underlined, bolded, and orange when they indicate a missense mutations. Rare missense mutations lacking research have a "?" after the rare allele, as it's not known if that rare allele is a down-regulation or an up-regulation.
rsID.........NAME....SLOWER...ETC
rs737866.....T689C...C.......Implied
rs737865.....A701G...G
rs4646312....T385C...T.......Implied
rs165722.....C201T...C.......Implied
rs6269.......A98G....A
rs6270.......C34S....C?
rs4633.......H62H....TT
rs6267.......A72S....T
rs13306281...V92M....A?
rs61910731...V100L...T?
rs5031015....A102T...A?
rs4986871....A146V...T?
rs4680.......V158M...AA.....1/3 activity
rs13306279...P199L...T?
rs174696.....C1354T..C.......Implied
rs9332377....C367T...T
rs165599.....G522A...G
Haplotype I (only relevant when all of these versions are present):
rs4646316....C310T...C
rs9332377....C367T...T
Haplotype II (58-fold reduction in function when all of these versions are present):
rs6269.......A98G....A
rs4633.......H62H....C
rs4646312....T385C...T......See Note
rs4680.......V158M...G
Note: rs4646312 in Haplotype II is reported with the more common allele of rs4818 as the risk factor. 23andMe doesn't contain that SNP, but rs4646312 has identical and nearly identical prevalence rates in the various groups genotyped, hence is likely usually inherited in a "chunk" with rs4818. So the results of rs4646312 will usually be applicable, but might not be in some cases.
"Implied" slow alleles are based on studies where novelty seeking is associated the other allele, as novelty seeking has been associated with up-regulation. I'm not as confident in those sorts of studies, as they're basically making a lot of assumptions based on questionnaires and interpretations of behavior. Two haplotypes are listed at the end. These are only relevant when all of the alleles are present.
SNP names are underlined, bolded, and orange when they indicate a missense mutations. Rare missense mutations lacking research have a "?" after the rare allele, as it's not known if that rare allele is a down-regulation or an up-regulation.
rsID.........NAME....SLOWER...ETC
rs737866.....T689C...C.......Implied
rs737865.....A701G...G
rs4646312....T385C...T.......Implied
rs165722.....C201T...C.......Implied
rs6269.......A98G....A
rs6270.......C34S....C?
rs4633.......H62H....TT
rs6267.......A72S....T
rs13306281...V92M....A?
rs61910731...V100L...T?
rs5031015....A102T...A?
rs4986871....A146V...T?
rs4680.......V158M...AA.....1/3 activity
rs13306279...P199L...T?
rs174696.....C1354T..C.......Implied
rs9332377....C367T...T
rs165599.....G522A...G
Haplotype I (only relevant when all of these versions are present):
rs4646316....C310T...C
rs9332377....C367T...T
Haplotype II (58-fold reduction in function when all of these versions are present):
rs6269.......A98G....A
rs4633.......H62H....C
rs4646312....T385C...T......See Note
rs4680.......V158M...G
Note: rs4646312 in Haplotype II is reported with the more common allele of rs4818 as the risk factor. 23andMe doesn't contain that SNP, but rs4646312 has identical and nearly identical prevalence rates in the various groups genotyped, hence is likely usually inherited in a "chunk" with rs4818. So the results of rs4646312 will usually be applicable, but might not be in some cases.