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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I have just come across it and I was wondering if anyone here has heard of it or suffers from it?
I take aspirin regularly its the only thing that makes me feel better?? strange illness.....
Salicylate intolerance research goes back many decades, and many books have been written. In 1984 in Australia it was shown to be linked to the enzymes delta-5 and delta-6 desaturase, and when it damages them it causes symptoms. However to get there the liver has to fail detox, and the gut, and you have to have limited desaturase capacity. Insufficient reduced glutathione is implicated here. I cannot say more at the moment as I am about to go offline.
"Aspirin activates both glycolysis and mitochondrial respiration, and this means that it shifts the mitochondria away from the oxidation of fats, toward the oxidation of glucose, resulting in the increased production of carbon dioxide. Its action on the glycolytic enzyme, GAPDH, is the opposite of estrogen's."....