I suppose you'd have to say that the responses to this thread paint a pretty bleak picture. Reading the messages doesn't give anyone the slightest idea of which root to go down. There is no recurring theme. Every 6 months here in the UK I visit my local ME/CFS clinic. I have done this for the last 3 or 4 years. There isn't much point in doing this really but I like to know if she has had any useful feedback from other sufferers. You don't see an ME/CFS doctor at these appointments, you see an occupational therapist!! She says she doesn't know what to say really,'' the only thing I have to offer is CBT/GET she says''. I think far too much time is wasted on here discussing CBT/GET. Surely if there was any real use in this approach then sufferers would be strongly urged and advised to give it a go. I think we can deduce from the way my therapist mentions it that it's pretty useless. To me, in the UK, it's probably just an attempt to get people off benefits and back into work. They can't pin this one on me though as I do have a fulltime job. Which brings me to what I touched on in my original post, about techniques such as Gupta training, Mickel therapy and the Lightning process. The problem being though that these seem to be a bit taboo.But these seem to be the only areas where the word ''cure'' keeps appearing. For what it's worth suggesting I would like to see this happen. It was reported on here not so long back that at Newcastle University they had discovered an abnormaliity in our muscle cells. This would seem quite significant I'd have thought. Why not do a trial whereby get a group of people all who have classic ME/CFS symptoms and then confirm they have these muscle cell abnormalities. They then all learn the techniques of either say Gupta, Mickel therapy or the lightning process. All learning the same one of course. If some of the the stories scattered around the internet are true then some of these people should be cured. Then they could have a retest to see if their muscle cells were the same or had changed. I look forward to everyones opinions