Al Klein
Senior Member
- Messages
- 101
- Location
- United Kingdom (Buckinghamshire)
I currently take methyl cobalamin and methyl folate - feel OKish
Do I follow COMT guidelines or MTRR?
Do I follow COMT guidelines or MTRR?
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You can avoid most of the methyl problem by taking hydroxoB12 instead of methylB12. Methylfolate is still required if you have a MTHFR C677T mutation, but doses of methylfolate should be pretty effective at much lower doses than B12. So a normal dose of methylfolate, and then with hydroxoB12 you can go pretty high if you tolerate it.I currently take methyl cobalamin and methyl folate - feel OKish
Do I follow COMT guidelines or MTRR?
I currently take methyl cobalamin and methyl folate - feel OKish
Do I follow COMT guidelines or MTRR?
By the way rs6495446 is in the MTHFS gene not MTHFR
Have you looked at Valentijn's threads on interesting snps? So far there are ones for MTHFR, CBS, MTRR, VDR and probably more.
Thank you - that is the first time I've seen a link between my data and PA - lots for me to readHi Al Klein;
I see you have a couple of polymorphisms that are a big reason for pernicious anaemia. GIF is one, and TCN is another.
I don't know much about genetics, but I've come across these when reading about B12 deficiency.
http://www.mhprofessional.com/downloads/products/0071439153/SarafogluCh17.pdf
The above is a good link, but I had trouble printing it, ( ? ), so I'll try to get some more links for you to show to the doc.
My husband is having the same confusion about taking methyl-whatever. He has snps similar to @Al Klein.You can avoid most of the methyl problem by taking hydroxoB12 instead of methylB12. Methylfolate is still required if you have a MTHFR C677T mutation, but doses of methylfolate should be pretty effective at much lower doses than B12.