- Messages
- 12
Hello everyone
First post, new to the wacky world of methylation and since getting my 23andMe results last week have been in a state of anxiety and concern for me, my kids and my siblings and their kids. Plus doing a lot of research. Managed to aggravate family who don't understand significance and me telling them they must get tested also. Mother said she would rather not know etc..
However from what I have read being homozygous for C677T predicts a low Red Cell folate levels but when I was tested in 2011 using CLINIPATH Australia the level was 876 ug/L (267-1023) or 50 nmol/L which seems OK right? Homocysteine was 11.6 umol/L. At this time I did supplement for 3 months with sublingual b12 and follinic acid but never got re-tested.
Have purchased hydroxycobalamin and metafolin but don't want to dive in especially after reading about CBS and BHMT on heartfixer and need to test sulphur and ammonia levels which are probably high on my Very low Carb (on a good day) diet.
Main symptoms are chronic rsi type pain in wrists for last ten years, general fatigue and lack of energy, brain fog etc. 44 year old Male been on Paleo gluten free + dairy last three years.
Here are my results which seem to have a lot of reds and yellows
Really appreciate any advice on what to do next. I did get hair analysis for heavy metals and all low-normal but apparently it is not reliable.
Homozygous
ADD1 G460W rs4961 +/+
BHMT rs16876512 +/+
BHMT rs6875201 +/+
COMT H62H rs4633 +/+
COMT V158M rs4680 +/+
DAO rs3741775 +/+
GAD1 rs3791878 +/+
MTHFD1L rs17349743 +/+
MTHFR C677T rs1801133 +/+
MTHFS rs6495446 +/+
NOS3 rs3918188 +/+
Hetrozygous
AGT M235T/C4072T rs699 +/-
BHMT-04 rs617219 +/-
BHMT R239Q rs3733890 +/-
CBS C699T rs234706 +/-
DAO rs2111902 +/-
FUT2 rs492602 +/-
FUT2 rs601338 +/-
FUT2 rs602662 +/-
GAD1 rs2241165 +/-
GAD1 rs769407 +/-
GAD1 rs2058725 +/-
GAD1 rs3791851 +/-
GAD1 rs3791850 +/-
GAD1 rs701492 +/-
GAD1 rs769395 +/-
MTHFD1L rs6922269 +/-
MTHFD1L rs803422 +/-
MTRR A66G rs1801394 +/-
MTRR-11 A664A rs1802059 +/-
MTRR rs10520873 +/-
MTRR rs1532268 +/-
PEMT rs4244593 +/-
PEMT rs7946 +/-
SLC19A1 rs1888530 +/-
SLC19A1 rs3788200 +/-
TYMS rs502396 +/-
VDR Bsm rs1544410 +/-
Other labs that concern me are below though maybe not related to methylation
Test Type Test Sub Type Result Range Unit of measure
Thyroid Function Thyroid Stimulating Hormone (TSH) 0.92 0.4-3.5 Mu/l
Fasting Glucose 5.60 3.0-5.4 mmol/L
ANA 1.40
Thyroid - Blood Thyroid Stimulating Hormone (TSH) 1.20 0.40-3.50 mU/L
Thyroid Function Thyroid Peroxidase Ab (TPO) 34.30 <34 IU/mL
Cardiovascular Disease Risk - Blood Homocysteine 11.60 <7 umol/L
Iron Studies - Blood Ferritin 66.00 30-500 ug/L
Thyroflex Reflex 151.00
AdrenoCortex Stress Profile (ASI) - Saliva Cortisol Morning 72.70 6.0-42.0 nmol/L
AdrenoCortex Stress Profile (ASI) - Saliva Cortisol Daily Total 95.00 11.0-76.0 nmol/L
AdrenoCortex Stress Profile (ASI) - Saliva DHEAS/Cortisol AM Ratio 0.08 0.20-0.60 Ratio
Sex Hormones - Saliva Progesterone (P4) 1593.00 <159 pmol/L
Sex Hormones - Saliva Estradiol (E2) 40.00 <6 pmol/L
Sex Hormones - Saliva Estrone (E1) 50.00 9.6-20.0 pg/mL
Hair mineral Analysis Calcium 168.00 22-97
Hair mineral Analysis Potasium 1.00 2-24
Hair mineral Analysis Molybdenum 0.00 .003-.008
Thyroid Function - Blood Thyroid Stimulating Hormone (TSH) 1.08 Mu/l
Thyroid Function - Blood Thyroid Peroxidase Ab (TPO) 70.00 IU/mL
First post, new to the wacky world of methylation and since getting my 23andMe results last week have been in a state of anxiety and concern for me, my kids and my siblings and their kids. Plus doing a lot of research. Managed to aggravate family who don't understand significance and me telling them they must get tested also. Mother said she would rather not know etc..
However from what I have read being homozygous for C677T predicts a low Red Cell folate levels but when I was tested in 2011 using CLINIPATH Australia the level was 876 ug/L (267-1023) or 50 nmol/L which seems OK right? Homocysteine was 11.6 umol/L. At this time I did supplement for 3 months with sublingual b12 and follinic acid but never got re-tested.
Have purchased hydroxycobalamin and metafolin but don't want to dive in especially after reading about CBS and BHMT on heartfixer and need to test sulphur and ammonia levels which are probably high on my Very low Carb (on a good day) diet.
Main symptoms are chronic rsi type pain in wrists for last ten years, general fatigue and lack of energy, brain fog etc. 44 year old Male been on Paleo gluten free + dairy last three years.
Here are my results which seem to have a lot of reds and yellows
Really appreciate any advice on what to do next. I did get hair analysis for heavy metals and all low-normal but apparently it is not reliable.
Homozygous
ADD1 G460W rs4961 +/+
BHMT rs16876512 +/+
BHMT rs6875201 +/+
COMT H62H rs4633 +/+
COMT V158M rs4680 +/+
DAO rs3741775 +/+
GAD1 rs3791878 +/+
MTHFD1L rs17349743 +/+
MTHFR C677T rs1801133 +/+
MTHFS rs6495446 +/+
NOS3 rs3918188 +/+
Hetrozygous
AGT M235T/C4072T rs699 +/-
BHMT-04 rs617219 +/-
BHMT R239Q rs3733890 +/-
CBS C699T rs234706 +/-
DAO rs2111902 +/-
FUT2 rs492602 +/-
FUT2 rs601338 +/-
FUT2 rs602662 +/-
GAD1 rs2241165 +/-
GAD1 rs769407 +/-
GAD1 rs2058725 +/-
GAD1 rs3791851 +/-
GAD1 rs3791850 +/-
GAD1 rs701492 +/-
GAD1 rs769395 +/-
MTHFD1L rs6922269 +/-
MTHFD1L rs803422 +/-
MTRR A66G rs1801394 +/-
MTRR-11 A664A rs1802059 +/-
MTRR rs10520873 +/-
MTRR rs1532268 +/-
PEMT rs4244593 +/-
PEMT rs7946 +/-
SLC19A1 rs1888530 +/-
SLC19A1 rs3788200 +/-
TYMS rs502396 +/-
VDR Bsm rs1544410 +/-
Other labs that concern me are below though maybe not related to methylation
Test Type Test Sub Type Result Range Unit of measure
Thyroid Function Thyroid Stimulating Hormone (TSH) 0.92 0.4-3.5 Mu/l
Fasting Glucose 5.60 3.0-5.4 mmol/L
ANA 1.40
Thyroid - Blood Thyroid Stimulating Hormone (TSH) 1.20 0.40-3.50 mU/L
Thyroid Function Thyroid Peroxidase Ab (TPO) 34.30 <34 IU/mL
Cardiovascular Disease Risk - Blood Homocysteine 11.60 <7 umol/L
Iron Studies - Blood Ferritin 66.00 30-500 ug/L
Thyroflex Reflex 151.00
AdrenoCortex Stress Profile (ASI) - Saliva Cortisol Morning 72.70 6.0-42.0 nmol/L
AdrenoCortex Stress Profile (ASI) - Saliva Cortisol Daily Total 95.00 11.0-76.0 nmol/L
AdrenoCortex Stress Profile (ASI) - Saliva DHEAS/Cortisol AM Ratio 0.08 0.20-0.60 Ratio
Sex Hormones - Saliva Progesterone (P4) 1593.00 <159 pmol/L
Sex Hormones - Saliva Estradiol (E2) 40.00 <6 pmol/L
Sex Hormones - Saliva Estrone (E1) 50.00 9.6-20.0 pg/mL
Hair mineral Analysis Calcium 168.00 22-97
Hair mineral Analysis Potasium 1.00 2-24
Hair mineral Analysis Molybdenum 0.00 .003-.008
Thyroid Function - Blood Thyroid Stimulating Hormone (TSH) 1.08 Mu/l
Thyroid Function - Blood Thyroid Peroxidase Ab (TPO) 70.00 IU/mL