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Well, idk. I have VERY high histamine - my allergies are the worst my allergist has ever seen, and the only methylation supplement that sets them off is niacin. Niacin sets everyone off but for those of us who are sensitive the reaction is very severe and long lasting. Presumably not dangerous except it will ruin your day and scare th ecrap out of you. P5P is SO good for you - it also protects your kidneys from glycation caused by blood sugar and Life Extension says a huge percentage of those with kidney disease could have avoided it with P5P. It is considered an important life extender for that reason.GenDylan, my immediate full red-face, red-body histamine reaction went down. I did a few charcoal flushes and have been taking molybdenum. I have no idea if they helped or not. I am still in the same boat though, my histamine is still crazy high. I'm so scared of taking something that would set off the histamine chain again. I can't handle another night like that. Almost went insane. Right now I'm trying methyl-B12, as my research shows a functional deficiency could have caused the reaction to the folate +TMG, but it's too early to tell. It's definitely doing something and I'm way more emotional and a little more itchy. Detox? Making me worse? Who knows. The thing that is written for high-histamine types is to take l-methionine. It's been recommended to me twice now, but I'm so scared to try it after what TMG did. Let me know if you find something that works.
I am sure P5P is lowering your anxiety. It appears it is lowering your itchiness. (This is not a symptom I ever had because I have taken 100mg B6 my whole life). I do NOT BELIEVE it is lowerig your HISTAMINE. I have EXTREMELY bad allergies and they are not phased AT ALL by any methylation supplement in any dose. The only "allergic" symptom that is cured by methylation is itching from bug bites - a mere skin allergy...it does NOTHING for systemic allergies. So...the story is a lot more complicated than you make it appear and you cannot say that it lowers histamine w/o testing to prove it.OMG. UPDATE!!!!!!!!!!!!!!!!!!!!!!!
P5P is lowering my histamine !!!! At least I think so! My body doesn't feel feverish to touch. I haven't had a hot flash. So far I've taken 100mg of p5p. I'll take some more tonight.
I believe I'm deficient in zinc,which would make me deficient in p5p. My dao enzyme has life is coming to life I believe!
God if this continues it'd be so great. Lower histamine means less anxiety. Thus because Adrenaline is a main counter to histamine.
You should get your hair analyzed before you jump to conclusions about copper. estrogen helps women absorb copper, for example. Men and women are usually high/normal in copper when they are young due to hormonal help. You can get a tracelements.com hair analysis here:pgoody whenever I get really excited, I get the histamine symptoms. Also when I go outside and it's really hot out, I get histamine symptoms, always when I get in a super hot car I get super itchy. Not only do I get itchy, I get hot. Also I get remarks on my body where I haven't even itched, my forehead and neck particularly .
Cortisol and adrenaline are histamines main counters, my histamine would not be a problem if I had sufficient cortisol. But I don't, my cortisol is flatlined I believe.ill be testing this week, and then taking hydrocortisone. In the mean time while my cortisol is low, adrenaline is all I got to counter the histamine. I get a rush of adrenaline on command, butterflies in my stomach. I'm paranoid and nervous about everything, ridiculous general and social anxieties. This constant surging of adrenaline leaves me fatigued, including my brain - I've had 24/7 brain fog for at least about 2 years,,,along with the fact that my energy is so low I could be bedridden. My body doesn't want to stand, my legs want to give out. My body's high need for adrenaline is also depriving me of dopamine,because dopamine converts into epinephrine(adrenaline),my dopamine is constantly being converted and being robbed from me. The low dopamine and high adrenaline causing ADHD and a super wiredness,while being physically SO tired.
So, histamine is a big,big key for me.once I start having adequate levels of cortisol in me, I want my histamine to be manageable for just the cortisol. If my histamine is too high to where my cortisol can't get rid of it, then my adrenaline will still be higher than I'd like. FYI, I once took a cortisol suppressing supplement at night(seriphos) , once it kicked it in I got a histamine reaction. Major hot flash. I knew not of hot flashes until LMethionine..
And The reason that I'm now reluctant to use Vitaman C to lower my histamine ,is because I recently read that VitC helps a lot with the conversion of Dopamine to Nonepinephrine. Although VitC is GREAT at lowering histamine , I can't stand to lose any more dopamine. My dopamine is so low, I can't focus, I'm depressed with ZERO motivation,not even to brush my teeth,,,and I get euphoric at anything that makes me happy. I'm so sensitive to dopamine because I'm so low. Btw,depression with low motivation is typically dopamine,not serotonin ,actually new studies say dopamine is much more important than serotonin /serotonin is overrated in terms of depression.
Btw I've had all of these symptoms,since I was 5 years old, they've just progressed significantly. And I didn't know histamine was a problem until I started LMethionine. I suspect I've always had low cortisol and methylation problems..
dishwashsoap 1st of all I'm very happy for you that your histamine issue has resolved.i wish stress upon nobody. Also, it is veryyy encouraging that b6 has helped you so much. Thanks for pushing me this direction, really appreciate it.
I too believe that I could have a copper problem. Thus because I believe I have low zinc and high estrogen. high estrogen because I have man boobs w/o working out or having much fat on my body. Low zinc because I didn't flush during the niacin histamine test, I did get hot tho, and this was before LMethionine which raised my histamine. I've read that you need zinc to flush from Niacin..
I really can't wait to do my 23andme test , the price is amazing.