There's also a bigger picture. A confirmatory trial of Rituximab will mean a step-change in how our disease is seen. Rituximab is an immune drug, not a talking therapy or exercise. It will mean we are seen as having an immune disease - which we most certainly do, whether it's auto-immune or not, or has other components such as neurological and so on - and will legitimise our illness, get many more scientists and clinicians interested, and open the floodgates to funding. Any successful confirmatory trial of any immune drug - Rituximab, Ampligen, Valcyte - for ME will do this. At the moment, Rituximab looks very promising and that's why so much effort is going into funding it..