B12 working but can't sleep.....

[Lotus97]

I do but I don't suffer from a lot of the symptoms that I read about here as I figured out pretty fast why I was dizzy and tired. It actually all started from a yeast infection oddly enough. But anyway, I feel pretty good when I take it but if I take too much I can't sleep. Judging by the great reviews of it on iHerb.com I definitely think it's worth trying. I've also been messing around with metafolin but don't want to continue until I get a mthfr test done to make sure I actually need it.

You need both B12 and methylfolate for methylation. People do get positive benefits from just B12, but you will experience better results from methylation. It might take a couple months of doing methylation before you notice improvement although some people do experience improvement at the beginning of methylation. Also, some people aren't able to tolerate a high dose of B12 and methylfolate so it would be good to start low. 200 mcg or less of methylfolate.

 

[TPOBPAH]

Yes, I realize that but you're assuming I'm not absorbing enough methylfolate through diet which has yet to be proven in my case. I know b12 for sure though.

 

[TPOBPAH]

I've also tried Jarrows b12 and my yeast infection went into hyperdrive. I had some at work and a female friend of mine who suffers from yeast infections off and on tried one because she was tired and hers got really bad as well. Very strange indeed!

 

[Lotus97]

Yes, I realize that but you're assuming I'm not absorbing enough methylfolate through diet which has yet to be proven in my case. I know b12 for sure though.

dbkita seemed to think that the type of folate in plants wasn't as usable as reduced forms of folate such as folinic acid and methylfolate.

 

[SanDiego#1]

This has happened before but only when I take the type of methyl b12 that you swallow opposed to a sublingual under the tongue. It just doesn't make any sense.[/qu
LOTUS
No one here taking Hydroxy b-12 injections? I know a lot of people that are using these 1 cc a day no pres. with insulin needle and syringe.. Works in 5 min and I have had no side effects. Give Sub-Q. Compounded--.Even if you don't like shots-these are easy. Be very careful with the Magnesium. I had all kinds of digestive upsets and the longer I took it the worse it got. Also made be Lethargic and depressed. I can see where it would help Restless leg syndrome. You may also be Dehydrated.

Best,

San Diego #1

 

[Lotus97]

LOTUS
No one here taking Hydroxy b-12 injections? I know a lot of people that are using these 1 cc a day no pres. with insulin needle and syringe.. Works in 5 min and I have had no side effects. Give Sub-Q. Compounded--.Even if you don't like shots-these are easy. Be very careful with the Magnesium. I had all kinds of digestive upsets and the longer I took it the worse it got. Also made be Lethargic and depressed. I can see where it would help Restless leg syndrome. You may also be Dehydrated.

Best,

San Diego #1

What was this in response to? You quoted TPOBPAH's post, but you mentioned my name.

 

[South]

@dbkita Can I ask, do you have sources for info you like to use...If so, I'd like to read them. For example, in a post in this thread you commented that norepinephrine somehow aggravates inflammation, yet in the ordinary info sources that I go to I've seen the opposite - I'm thinking my sources for info aren't very up to date.
Here's one of the sources mentioning norepinephrine lowering inflammation, rather than raising it (so they say)
https://www.novapublishers.com/catalog/product_info.php?products_id=13573

 

[SanDiego#1]

Like many, my dr. is ill trained for lack of b12 so I'm treating myself. I will lay everything out in point form as to not waste time and for clarity.

35 yr old male.

Diagnosed approx 5 months ago with a level of 168.

Initial symptoms were: major fatigue, off balance, slow heart rate, poor sleep, shortness of breath.

Started on Natural Factors methyl b12 sublingual working my way up to 10,000 a day.

Had levels checked and they were just over 1000.

Symptoms now much improved except I can't sleep, up every hour tossing and turning, very little deep sleep.

I did have sleeping problems prior due to long term stress but was sleeping better until symptoms of low b12 appeared around 7-8 months ago.

I've tried just taking doses at different times of the day to no avail.

Also quit taking supplements for 4 days and it seems the symptoms are already returning.

Any recomendations out there to help get some sleep?

Thanks very much!

How much P5p and methylfolate do you take?

What was this in response to? You quoted TPOBPAH's post, but you mentioned my name.

 

[SanDiego#1]

TROBPAH- Before you do anything see a sleep specialist. Let them do an overnight study . I did and am on a CPAP.
machine.Stopped all my sleep issues and most of my Palpitations. Neurologist told me you cn take 9 mg if needed in melatonin. However., I would to be on the safe side have a sleep specialist do the study. I had actually stopped breathing over 30 times during the night and did not know it-until the sleep study found it. A Pulmonary sleep specialist is best. Well worth the time and investment.

Best-

San Diego #1

 

[Coolie]

@TPOBPAH I am in the same boat as you re the B12, I take 5000mcg a day which has done some amazing things, and even cured a myriad of problems, but other than an additional B complex tablet, I don't take methyfolate. I have always needed a lot of sleep and slept very solidly all my life until now, and I am awake at 2, 3, 4, 5, 6. It's not great but testament to the real amazing things B12 has done that I would not give it up however annoying sleep disturbance gets. Having said all this, sometimes it goes on for 2 or 3 nights and then I do get a good nights sleep, so it's not always that bad.

 

[Melissaolivo]

I was given one shot 100,000 mcs b12 when I was a little low not deficient, I really don't know why my dr gave it to me my range was like 440. Anyway it shot me into overload heart rate racing for two weeks night sweats insomnia. Now my heart rate has slowed a lot down, but still can't sleep. It's been a month. I have never had trouble sleeping. What does it do to someone who shouldn't have been given the shot? Isn't there anything to counteract what the shot did to me? I am missing my sleep. Anyone have any suggestions?

 

[PeterPositive]

I was given one shot 100,000 mcs b12 when I was a little low not deficient, I really don't know why my dr gave it to me my range was like 440. Anyway it shot me into overload heart rate racing for two weeks night sweats insomnia. Now my heart rate has slowed a lot down, but still can't sleep. It's been a month. I have never had trouble sleeping. What does it do to someone who shouldn't have been given the shot? Isn't there anything to counteract what the shot did to me? I am missing my sleep. Anyone have any suggestions?

Are you sure it is 100 000? Could it be 10 000 instead?
In any case it sounds like you didn't react too well to it. With time it is expected that the side effects will go away.

You could take some valerian root, Passion flower and/or ashwaghanda to help relaxation and sleep. Also vitamin B3 could work as an "antidote" by soaking up the excess methyl group, although the side effects are not necessarily tied to speeding up the methylation. I think you should consult your doc and explain what happened.

Good luck

 

[Melissaolivo]

Are you sure it is 100 000? Could it be 10 000 instead?
In any case it sounds like you didn't react too well to it. With time it is expected that the side effects will go away.

You could take some valerian root, Passion flower and/or ashwaghanda to help relaxation and sleep. Also vitamin B3 could work as an "antidote" by soaking up the excess methyl group, although the side effects are not necessarily tied to speeding up the methylation. I think you should consult your doc and explain what happened.

Good luck

Hi peter,
Is this called excitotoxicity ? Can this stay for months or years? Is there any treatment?or dr that can help me with this I have been living a nightmare. Thanks melissa

 

[PeterPositive]

Hi peter,
Is this called excitotoxicity ? Can this stay for months or years? Is there any treatment?or dr that can help me with this I have been living a nightmare. Thanks melissa

Yes, it could be that. Over excitation of the nervous system causing anxiety etc... but one B12 will not give you lasting side effects. B12 is flushed out of the system pretty quickly, something else is going on.

 

[Melissaolivo]

Thanks again Peter for your reply. So have other people you know that have had excitotoxicity did it go away on its own or did they need some treatment?thanks Melissa

 

[Melissaolivo]

I had taken one 1000 iu of the b12 vitamin prior had the same reaction. You do not know how to covert mcgs to iu's by any chance?

 

[Melissaolivo]

Do you know the best specialist to see for adverse reactions to b12 to order special bloodwork and such?

 

[PeterPositive]

Thanks again Peter for your reply. So have other people you know that have had excitotoxicity did it go away on its own or did they need some treatment?thanks Melissa

As I wrote in my previous post vitamin B3 seems a good "antidote" to excessive anxiety caused by B12 and folate. This has been reported multiple times by people in this forum and several doctors.
Calming, anti-anxiety herbs can also have a positive effect (again see my previous post). My first recommendation though, would be to speak with your doc because it sounds there are other problems going on.

I had taken one 1000 iu of the b12 vitamin prior had the same reaction. You do not know how to covert mcgs to iu's by any chance?

i have no idea, I am sorry.
I have never heard B12 is also dosed in IU. Most of the scientific literature uses either mcg or mg.

Do you know the best specialist to see for adverse reactions to b12 to order special bloodwork and such?

No, I am sorry.

cheers