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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Check out the links in my signature.
Caledonia, I've been meaning to comment on this great set of links you have in your signature. well done.
Sregan, most of my SNPs are +/-. Yet they've had a huge negative impact on my life. Caledonia's summary for you is right on target. ahmo
On Yasko's Simplified Roadmap, she has treating glutamate imbalance first. This would be good to do if you're one of those "tired but wired" people, anxious, problems with sleep etc.
You don't have the First Priority Mutations, SHMT or ACAT, so then you would skip to CBS.
You're +/- for CBS C699T, which is the big one. So you need to determine if that's expressed. If you're sensitive to sulfur foods/supps/meds, or you have high urine sulfate and ammonia, or you have a stress/anxiety reaction to methylation supps, these are clues you'll need to address CBS. Heartfixer has a good CBS protocol. However, you can follow a low free thiol diet instead of a low sulfur diet, which is less restrictive and it still works. I also didn't limit meat, just took yucca, and it still worked.
Then once that is resolved, you can add the other methylation supports. You're going to need TMG (such as in Yasko's general health formula) to support the secondary pathway. You'll need methylfolate for the MTHFR mutations and B12 for that and the MTR/MTRR mutations. Because of your COMT and VDR mutations, you may or may not do ok with straight up methylcobalamin. Yasko has a nice chart on her Simplifed Roadmap for what forms go with what SNPs.
Check out the links in my signature.
I'm also trying to learn and read about this stuff but its very complicated. Caledonia if you have time to post anything that stands out about my results I would be very thankful.
Methylation Analysis
I had posted this in the wrong place. Please any help would be appreciated. I have already researched some of this.
Methylation Panel
Detox Panel