dbkita
Hi; Yes, it probably doesn't seem fully logical that 400 mgs. of riboflavin would be absorbed and utilized, but for these past 30-some days, I've been taking as much as that in divided doses. ( usually 100mgs. at a time, sometimes less)
All I can write about it is that it works against my inflammatory headaches. The only side effect I've noticed is a mildly dry mouth. ( not eyes)
I learned of this protocol about 8 yrs. ago, when I was struck down with a daily continuous migraine for 4 mnths. I took alot of things for it including: clonazepam, progesterone, 5htp w/B6, and tyrosine. Then, I found Drs. Mauskop and Fox's book about treating migraines with a triple therapy of : magnesium 400mg., riboflavin 400mg., and feverfew 100mg. (herb) , daily, in divided doses. It worked, in time. At that time, I thought it was the magnesium that was the most effective element for migraine. ( It usually is) But, in recent years, I became physically intolerant of mg. ( tested highest normal in blood serum too.)
The migraines only returned in these last 4mths., after I greatly increased B12 and folate. ( I'm still intolerant of folate supplementation, unfortunately)
From what I've read about B2 therapy, it may take a few months to rectify this migraine situation, so I don't plan on taking such high dosages long term. ( I'm sure it could cause other problems, unknown) But, it has truly helped me out of this self-induced 'overmethylation', possible hypermethylation situation.
Although it hasn't effected my sleep, and has not overstimulated me, I would certainly caution other folks about these potential side-effects.
I would suggest that, if someone is having trouble with a methylation protocol, extra B2 may be helpful, along with reducing the dosages of the other supplements.