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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I know you just said you "don't know what to say there", but I'm going to ask anyways because you usually do have an answer for everything. Do you think it has to do with deficiency as some people have suggested? And since you didn't mention SNPs, does that mean you don't think the reaction is due to certain SNPs? My symptoms continued for 5 weeks until I stopped methylfolate. I suppose someone could make an argument that the high dose of folic acid I was taking at the time was constantly causing a deficiency, but I'm not yet convinced.On the other hand I agree wholeheartedly that there is something very contradictory going when people react to "crumbs" as you put it, so violently. I don't know what to say there. Theoretically someone should not react really bad to 20 mcg of methylfolate but then not have problems eating meat. Couple of portions of animal flesh and they get the same amount of methylfolate.
I know you just said you "don't know what to say there", but I'm going to ask anyways because you usually do have an answer for everything. Do you think it has to do with deficiency as some people have suggested? And since you didn't mention SNPs, does that mean you don't think the reaction is due to certain SNPs? My symptoms continued for 5 weeks until I stopped methylfolate. I suppose someone could make an argument that the high dose of folic acid I was taking at the time was constantly causing a deficiency, but I'm not yet convinced.
The way I hear some people talk about methylation supplements is the same way drug addicts talk. I used to use drugs so I'm very familiar with that mindset. You get an initial bump of good feelings, but it doesn't last. You're on a rollercoaster of highs and lows trying to get back the euphoria you were feeling earlier. When I started getting depressed a few months ago I began taking B12 again and I did get a mood boost, but it didn't last. We're all adults here and everyone is free to do what they want, but I'm not sure messing around with your neurotransmitters is necessarily going to be problem-free in the long run.