Oxidative Stress May Be Target of New MS Drug

[Gemini]

http://www.nytimes.com/2013/03/28/b...is-approved-by-the-fda.html?ref=business&_r=0

3rd oral drug for MS is approved by the FDA-- Tecfidera.

Besides fewer side effects, it may target a pathway that protects the body from oxidative stress.

 

[SOC]

http://www.nytimes.com/2013/03/28/b...is-approved-by-the-fda.html?ref=business&_r=0

3rd oral drug for MS is approved by the FDA-- Tecfidera.

Besides fewer side effects, it may target a pathway that protects the body from oxidative stress.

That could be helpful for us since studies have shown we have excessive oxidative stress. Betcha none of us can get it easily, though.

 

[Marco]

For those interested, here's a little science on how dimethyl fumarate (DMF) may exert its neuroprotective effects :

Effects of dimethyl fumarate on neuroprotection and immunomodulation

Our main finding is that DMF at low concentrations protects neuronal cells from oxidative stress by elevating cellular glutathione, and that similar concentrations also reduce production of proinflammatory cytokines from splenocytes.

http://www.jneuroinflammation.com/content/9/1/163

 

[Waverunner]

What I never understood about oxidative stress and disease is the fact, that we already have thousands of anti-inflammatory substances. Most vitamins, minerals etc. are anti-inflammatory. So what's the difference between this new MS drug and other compounds? Does it address a special form of inflammation?

 

[Marco]

What I never understood about oxidative stress and disease is the fact, that we already have thousands of anti-inflammatory substances. Most vitamins, minerals etc. are anti-inflammatory. So what's the difference between this new MS drug and other compounds? Does it address a special form of inflammation?

What may be different is that it apparently stimulates the endogenous anti-inflammatory Nrf2 pathway.

Some previous discussion on this thread :

http://forums.phoenixrising.me/inde...oxidative-stress-increases-glutathione.19228/

 

[Gemini]

That could be helpful for us since studies have shown we have excessive oxidative stress. Betcha none of us can get it easily, though.

Perhaps Tecfidera and the oxidative stress studies will be discussed at the April 25-6 FDA meeting?

 

[MishMash]

Basically, Biogen took a common psoriasis drug in Germany, Fumaderm, and "did something to it" so now they can sell it for fantastically high amounts. This is completely absurd. How they were able to get a patent for this is beyond me. People wonder why Medicare is bankrupting us, and no employers want to provide health insurance.

Stock fund portfolio managers polled by the research firm the ISI Group on Wednesday predicted a price of about $51,000 a year, which would be roughly in line with prices of the injectable drugs, but less than the $60,000 a year list price of Gilenya.

 

[Waverunner]

What may be different is that it apparently stimulates the endogenous anti-inflammatory Nrf2 pathway.

Some previous discussion on this thread :

http://forums.phoenixrising.me/inde...oxidative-stress-increases-glutathione.19228/

Yes, could be. I still don't get it however. Most drugs have anti-inflammatory effects. So do we just need a super-anti-inflammatory substance and everything will be fine for most diseases?