Rand56
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Is it advantageous to take lactoferrin at the same time as iron or doesn't it really matter?
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I had actually been wondering about doing the Plasma Amino Acids from Doctors Data as a follow up, rather than the UAA and had it on my Do-List to check it all out and cost it...... so thanks for the prompt !Lactoferrin is a good idea when taking supplemental iron. I suggest though beef liver pills are far better than ferrous sulfate or the other forms as they have the bioavailable heme form. The other forms are asking for it imo with respect to gut flora. The lactoferrin helps to sequester iron for your own purpose as oppose to gut microbes.
Btw Branston ... a urine measurement is not as indicative as plasma one for long term trends. The urine ones can show issues due to genetic disorders and mineral insufficiencies but the plasma ones tell you more about the long term activity. There are exceptions of course. You can read up for instance on Metametrix's UAA and serum AA tests and how they lead to different interpretations.
Lactoferrin is a good idea when taking supplemental iron. I suggest though beef liver pills are far better than ferrous sulfate or the other forms as they have the bioavailable heme form. The other forms are asking for it imo with respect to gut flora. The lactoferrin helps to sequester iron for your own purpose as oppose to gut microbes.
Btw Branston ... a urine measurement is not as indicative as plasma one for long term trends. The urine ones can show issues due to genetic disorders and mineral insufficiencies but the plasma ones tell you more about the long term activity. There are exceptions of course. You can read up for instance on Metametrix's UAA and serum AA tests and how they lead to different interpretations.
Iron bisglycinate was still hard on my stomach. Only heme iron was ok and to be honest I find with r5p supplementation I just need to eat beef.hi dbitka
I do understand the heme iron food sources are best but what are your thoughts about iron bisglycinate? I heard it's gentler on the gut as far as stomach distress from taking it, but does gentler on the stomach equate to more of it being absorbed in the system, or does the bisglycinate just act more like a buffer taking away the stomach discomfort?
Iron bisglycinate was still hard on my stomach. Only heme iron was ok and to be honest I find with r5p supplementation I just need to eat beef.
If it has a nasty effect then by all means don't force the b2. Wonder why it makes your depression worse. Something else is up.
Depression from b2 means something odd. Irritability, anger, too much energy, anxiety... yeah sure but depression ? You need b2 for the krebs cycle. I don't know about a craze. What doses were having this effect?
Edit: since r5p is a rate limiting cofactor for the MTHFR enzyme could somehow increased methylation be causing depression?
Understood. I would still wonder if its impact on MTHF production is the key reason for your reaction. What sort of methylation support do you do now? The reason I ask is being on methylation support with zero intake of b2 except maybe tiny bits in food is asking for a build up of 5,10 methyleneTHF in the folate cycle.I'll have to make a clarification here for you. I do not have "typical" MDD. It's more of anhedonia/dysthymia. So when I say I felt more depressed from extra B2 it did not give me "typical" depressive symptoms with the irritability and high anxiety. I know the difference. I DID have typical MDD about 20 years ago. The extra B2 made me even more fatigued and when this happens to me, there is even less air in my balloon <body> so to speak which worsens my depression.
Understood. I would still wonder if its impact on MTHF production is the key reason for your reaction. What sort of methylation support do you do now? The reason I ask is being on methylation support with zero intake of b2 except maybe tiny bits in food is asking for a build up of 5,10 methyleneTHF in the folate cycle.
Depression from b2 means something odd. Irritability, anger, too much energy, anxiety... yeah sure but depression ? You need b2 for the krebs cycle. I don't know about a craze. What doses were having this effect?
Edit: since r5p is a rate limiting cofactor for the MTHFR enzyme could somehow increased methylation be causing depression?