I'm looking for a B complex without any folate folic acid/folinic acid/methylfolate. The only one mentioned here was BodyBio's which is quite expensive and has 8000mcg of biotin which I'm not sure I want.
I was wondering if anyone knows to what degree folic acid blocks folinic acid and methylfolate. I seem to have reacted to a low dose of methylfolate even when I was taking over 1000mcg of folic acid so I'm still unclear if I need to completely eliminate folic acid. It's so much more convenient to just take a b complex rather than everything individually since I'm already taking too many supplements.
Hi Lotus,
I use a very basic B-complex from NatureMade, B-Complex with C. It has no folic or B12. Then I add b1, b2, b3 pantethine, p5p, inositol, choline, biotin and scupt it with single item b vitamins. I wish the B-right didn't have any folic or I would take it in a second.
Folic acid and for fewer people I believe, folinic work something like this. I will describe the folic acid. At a low dose like 400mcg it might work quite well. For some people it doesn'rt work even at low levels, about 20%. About 30% can utilize amounts less than 800mcg. About 50% can utilize up to 800-1000mcg. The theory has been for about 30 years that unconverted folic acid can accumulate until it blocks the channel in some way and prevents l-methylfolate from getting to where it needs to get to. In many trial titrations of myself and others it appears that folic acid can block about 10 times as much l-methylfolate, is it is blocking. Sometimes it just isn't delivering the methylfolate where and when needed but isn't blocking it per se Folinic acid is very similar except that it has a longer halflife. It appears that it can block 10-20 times as much l-methylfolate and it appears to take several days to clear whereas folic acid clears in about 24 hours sufficienctly for methylfolate effectivness, depending upon degree of blocking.
The only way I know of to find out is to do a trial with no folic and no folinic. If it makes a large noticable difference you will notice. Then you can try various combinations and find out which you can take and which you can't.
There is a lot of ellimination of possiblities in all this in order to be sure of what is working. After one gets things working well it becomes easy to see what doesn't work and what does. In the end it all makes sense . Part of the problem is that only some pathways are well identified. I was able to define only those I experienced and others that were frequent enough and welll described. I'm hoping that the next few most frequent pathways can be further defined this year. It's taken 5 years to work out this folate business becasue so much of it is paradoxical.
So to describe folic acid, typically it starts low and positive with small doses as the dose increases it becomes proportionately more effective. Then at some point it tops out at maybe 50% of what is sufficient for healing and then heads down going down to perhaps minus 50%, a blaockage condition. However, without enough MeCbl it can also despite folate insufficiency it it is relatively more common than MNeCbl a person can then trigger into methyltrap an even worse folate deficiency symptoms set..