Hello fellow X-Men.
I have just discovered that I have the MTHFR A1298C homozygous mutation. I've been trying a blend of various protocols found here on Phoenix Rising as well as Dr. Ben Lynch and Dr. Amy Yasko.
I wanted to start a thread for those who also have this mutation so we might discuss and exchange knowledge specific to it. Tweaks in the protocols that may help; specific supplements that you've found useful; sites with useful studies and the like.
So far, it appears that those with this mutation may have neurological problems, reduced neurotransmitter production, elevated nitric oxide and peroxinitrite and low BH4 levels.
Anything insights helpful to those with this mutation would be most appreciated.
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I'll get the ball rolling with an interesting presentation I saw from Dr. Yasko regarding the importance of one of the elements depleted by the A1298C mutation: BH4
In the video she make the following interesting points:
BH2 to BH4 is inhibited by lead and aluminium.
Phenylalanine builds up (BH4 needed for conversion to Tyrosine) which inhibits serotonin and GABA production.
BH4 needed to convert ammonia to urea.
Need BH4 for NOS (Nitric Oxide Synthase) Dopamine, Epinephrine, Neurepinethrine.
BH4 needed to make CoQ10
BH4 - 3 Legged Stool can be hindered by the following:
CBS Upregulation (depletes BH4 faster for ammonia detox), MTHFR A1298C Mutation (not regenerating BH4)
Chonic Bacteria infection/ Aluminium (inhibits stabilization)
5-formylTHF may be needed in addition to 5-methylTHF
Light Therapy may increase BH4 levels
Hydrogen Peroxide H2O2 stimulates BH4 levels
Low Glutathione impares BH4, Dopamine & GABA. Low BH4 increases suseptiblity to toxicity, more sensitive to G depletion in absense of BH4.
BH4 - Ureas cycle - still works but generates superoxide: oxidative, neural damage & microglial activation.
BH4 needed for NO: must be balanced.
Vtamin C increases BH4 levels and NOS levels.
Royal Jelly: Amino acids and low dose form of BH4
Hydroxy B12 scavenging NO
Low BH4 leads to increased peroxynitrite which suppresses mitochonrrial energy production. Interferes with brain function and enhances excitotoxins.
Low Magnesium enhances excitotoxins.
Microglyia Activiation: The immune system of the nervous sytem.
Secretes cytokines, chemokines, eucisaboids, protesase, complement and a least two excitotoxins. cytokines are neurotropic during neurodevelopment but chronic activation can be distructive.
Spiralina and Apple limits overactivation. Helps recovery
I have just discovered that I have the MTHFR A1298C homozygous mutation. I've been trying a blend of various protocols found here on Phoenix Rising as well as Dr. Ben Lynch and Dr. Amy Yasko.
I wanted to start a thread for those who also have this mutation so we might discuss and exchange knowledge specific to it. Tweaks in the protocols that may help; specific supplements that you've found useful; sites with useful studies and the like.
So far, it appears that those with this mutation may have neurological problems, reduced neurotransmitter production, elevated nitric oxide and peroxinitrite and low BH4 levels.
Anything insights helpful to those with this mutation would be most appreciated.
--------------------------------------------------------------------------------------------------------
I'll get the ball rolling with an interesting presentation I saw from Dr. Yasko regarding the importance of one of the elements depleted by the A1298C mutation: BH4
In the video she make the following interesting points:
BH2 to BH4 is inhibited by lead and aluminium.
Phenylalanine builds up (BH4 needed for conversion to Tyrosine) which inhibits serotonin and GABA production.
BH4 needed to convert ammonia to urea.
Need BH4 for NOS (Nitric Oxide Synthase) Dopamine, Epinephrine, Neurepinethrine.
BH4 needed to make CoQ10
BH4 - 3 Legged Stool can be hindered by the following:
CBS Upregulation (depletes BH4 faster for ammonia detox), MTHFR A1298C Mutation (not regenerating BH4)
Chonic Bacteria infection/ Aluminium (inhibits stabilization)
5-formylTHF may be needed in addition to 5-methylTHF
Light Therapy may increase BH4 levels
Hydrogen Peroxide H2O2 stimulates BH4 levels
Low Glutathione impares BH4, Dopamine & GABA. Low BH4 increases suseptiblity to toxicity, more sensitive to G depletion in absense of BH4.
BH4 - Ureas cycle - still works but generates superoxide: oxidative, neural damage & microglial activation.
BH4 needed for NO: must be balanced.
Vtamin C increases BH4 levels and NOS levels.
Royal Jelly: Amino acids and low dose form of BH4
Hydroxy B12 scavenging NO
Low BH4 leads to increased peroxynitrite which suppresses mitochonrrial energy production. Interferes with brain function and enhances excitotoxins.
Low Magnesium enhances excitotoxins.
Microglyia Activiation: The immune system of the nervous sytem.
Secretes cytokines, chemokines, eucisaboids, protesase, complement and a least two excitotoxins. cytokines are neurotropic during neurodevelopment but chronic activation can be distructive.
Spiralina and Apple limits overactivation. Helps recovery