I trust Rich. He was very knowledgeable in the areas of both methylation and mercury toxicity. He worked with people dealing with both issues in addition to consulting with various doctors. He has said that toxins, including metals can and most likely will be released during the process of methylation. This is different than the issue of methylcobalamin methylating mercury although there has been a study to suggest that this too is possible.
I don't see how this answers her question. You've said a lot of things that sound convincing to the average reader, but you haven't really provided any actual evidence. Sushi is very busy now and has asked you this question twice already. There are many people here who suspect mercury toxicity and are looking for answers. If you don't know then just say so.
Hi Lotus,
You know, if everything were "proven" and correctly so, none of us would be sick as we are or have been. So you are saying that we should not consider the science that is available on these issues, to collect information across many different studies and apply it if it conflicts with somebody's belief systems? The claims being made concerning MeCbl don't mesh with all sorts of studies. I've been writing serum haflife simulations, using pharmacodymamic data for dozens of medications for 20+ years.
Mercury in our bodies is a very widespread phenomina. I had a bunch of amalgams. I played with metallic mercury. Lots of people may have varying degrees of problems becasue of mercury. WHat I am syaing is that WHATEVER EFFECT MECBL HAS ON MECURY MUST FIT INTO KNOWN CONSTRAINTS concerning MeCbl and monomethylmercury. Becasue of sufficient surviving monomethylmercury poisoning events (Japan for instance) we have numerous excellent serum half life measurements studies. During the just about every study dione for a long time throuw in the serum halflfe measusrements on whatever forms they were working with. Establishing daily oral equivalence to injections included all ranges of time periods with serum measurements. In addition the unchanged nature of the cobalamin being excreted in urine for 24 hour accumulations was measured as well. Within those constraints, we are talking about some small number of micrograms, for HyCbl, MeCbl, AdoCbl, CyCbl that is retained in the body. And if you prefer 98% excretion to 99% excretion UNCHANGED in 24 hours or 48 hours you may prefer, a case could be made for any of the them. However, on 1000mcg absorbed by injection only leaves 10 or 20 or maybe even 30 mcg behind, lets be generous. All the entire effects in the body, all the detoxing, all of everything is done by the 10 or 20 or 30mcg left behind. The same is true with AdoCbl, all the effects it has, anti-inflammatory, mitochhondria, etc are due to the 10 or 20 or 30 mcg left behind. The differences by larger dose appears to be mostly a deth of penetration effect. What affects that is cyanide poisoning, glutathione, nitrous oxide, arsenic and probably a few more things that combine with it until one or the other are no longer available. Mercury does not act like that, clearly. With so much of the population carrying some mercury load that is bound to be reflected in the urine excretion resuts. So anything assuming that some huge bulk of MeCbl is acting as massive methyl donors just isn't a good explanation. It has to be excreted unchanged, regardless of types. There are a few toxins that change that. And those produce a cobalamin product that comes out the kidneys generally.
And you might be interested to know that NAC and glutathione cause mercury to be deposited in the brain at least according to one source.
I'm not disputing people have all sorts of heavy metals and other toxins. That complicates matters. However, there are constraints. As much as I fault CyCbl and HyCbl research, I agree that for things like serum levels and halflife and so on they probablay can do that quite well. The serum halflife of all involved substances, toxic effects, toxic levels (hypersensitivity can occur to mercury). If you want to make a case that mercury is reacting at a very fast rate with MeCbl, there needs to be evidence. Dr Cutler has stated that as far as he is concerned IF MeCbl and Hg react in vivo tyhen they dp so very slowly and at very low levels. That is what the evidence suggests. An interesting study would to be start somebody on MeCbl who has a lot of mercury, take a series of fecal Hg for basline and then daily for 4 months and derive the rate of reaction for that. Further it would build by the day for about 700 days until it has leveled out with that 71 day serum halflife. These are some predicitons that can be made based on known scientific evidence. The amount so deposited would allow us to calculate the number of mcgs of mercury and MeCbl reacted daily. Now that would be evidence. As no pharmaceutical company is going to make billions off of that it will come from a university. It probably isn't sexy enough to garner much desire to do such a study. Until somebody runs that study. If somebody has done that I would like to read it