Just seen my gp and he went through all my bloods. No hepatitis etc. He had tested for autoimmune stuff and gastric parietal antibodies came back negative this time. I said it was positive in June but he said its not now. I mentioned if my body could be storing vit b12 but not using it and he said no because ny red blood cells would be large and they aren't. He said wait for ultrasound on my liver and if it's ok just take my bloods again and see if my liver enzymes have gone back to normal. If its still high to see a liver specialist.
I am stumped as what to do! Do I take the methy b12 and methylfolate and ignore the high vit b12 levels in my blood?
Hi Fuzziehead!
Quite a disappointing visit! Pity.
Like I said:
After supplementing B12 the parietal antibodies can be false-negative.
It was positive in June, you can't simply ignore that, to my knowledge there are no false positives.
About the red bloods cells being enlarged. That's not true. IIRC that's also mentioned in that video I advised you to see.
In 1990 Lindenbaum, Stabler et al published 'Clinical spectrum and diagnosis of cobalamin deficiency' in which they wrote that 44% of the examined patients with a B12 deficiency had no anaemia, 36% had no macrocytosis.
I have understood that because of that (i.e. no anaemia and no macrocytosis in many cases) Pernicious Anaemia isn't the best name to use, PA is confusing. It would be better to speak of Addison-Biermer's disease, at least that's what I have read.
Perhaps googling 'Addison-Biermer's disease' will lead to information that could be helpful when talking to your GP next time.
I'll give you some links too, leading to studies written in the English language and English sites. I have more studies in my own language, but that'll be no good for you when facing your GP.
I guess that there are articles amongst them you'll dismiss as being unrelevant. But I have learned that in some of those unrelevant articles there can be information hidden that might impress a Dr.
I have not read them all, sorry. I just hope you'll find something that will be useful to convince your GP to act differently.
I have these articles from a Dutch site about B12 deficiency, the man behind it is familiar with doctors who are in the dark when it comes to B12 deficiency. So I think most of the links are worthwhile.
I know some of the articles provide information concerning the best treatment that differs from the things you'll read here, on Phoenixrising.
You'll have to be the judge on what's best to do, and what's best to supplement, after having read information given here on Phoenixrising.
If I were you I'd ignore the high B12 blood level and start supplementing.
I myself am using methylB12 and Methylfolate (and a lot of other things). But people here don't always agree on what's best the best approach. It's all very individual, what works for one does not work for the other. Brands, amounts, etc. You'll have to figure it out yourself and see what's best for you.
Please do read the threads and protocols about methylation, and follow the link Fredd has given too. It gives a nice insight in the local disagreements too.
Pernicious Anaemia
http://home.kpn.nl/hindrikdejong/pa-artikel-eng.pdf
Vitamin B12 Deficiency
http://home.kpn.nl/hindrikdejong/979.pdf
Challenges in the identification of Cobalamin-Deficiency Polyneuropathy
http://home.kpn.nl/hindrikdejong/1296.pdf
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Diagnosis
http://www.dach-liga-homocystein.org/EN/Fachinfo/B12/diagnostik.htm
Functional Vitamin B12 Deficiency Represented by Elevated Urine Methylmalomic Acid Levels in Patients with Migraine
http://home.kpn.nl/hindrikdejong/Migraine-MMA.pdf
Recurrent Seizures: An unusual manifestation of vitamin B12 deficiency
http://home.kpn.nl/hindrikdejong/epilepsie.pdf
Catatonia and other psychiatric symptoms with vitamin B12 deficiency
http://home.kpn.nl/hindrikdejong/ActaPsychiatrica-2003.pdf
Homocysteine, folate and vitamin B12 deficiency in neuropsychiatric diseases: review and treatment recommendations
http://www.dach-liga-homocystein.org/Fachlit/konsensus/neurodegen_EN
Plasma vitamin B12 status and cerebral white-matter lesions
http://home.kpn.nl/hindrikdejong/EMC-laesies-B12.htm
In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18056804
Total homocysteine and its predictors in Dutch children
http://home.kpn.nl/hindrikdejong/Am-Journ-Clin-Nutr-2006.pdf
How I treat cobalamin (vitamin B12) deficiency
http://bloodjournal.hematologylibrary.org/content/112/6/2214.full.pdf
Disorders of cobalamin (Vitamin B12) metabolism: Emerging concepts in pathophysiology, diagnosis and treatment
http://home.kpn.nl/hindrikdejong/Solomon-B12-2006.pdf
Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing
http://home.kpn.nl/hindrikdejong/Solomon-blood-2005.pdf
Laboratory Diagnosis of Vitamin B12 and Folate Deficiency
http://home.kpn.nl/hindrikdejong/Snow-B12.pdf
Vitamin B12 deficiency Support Group (Charity)
http://www.b12d.org/
Vitamin B12 deficiency
http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/20862.html
Many articles on Vitamin B12
http://vitaminb12.researchtoday.net/g