Thanks again. You seem to have an answer for everything
Your conversations with Adreno has been very helpful (although much of it I need to reread at least a few more times before I can understand it). That was actually where I first began to suspect Norepinephrine (NE). I remember you mentioning something about methylation increasing NMDA so that could be a factor also?.
Lol I wish I had answers. Just trying to do my part. Rich Vank helped me out of a jam when things were bad in 2010.
Over methylation can increase glutamate (especially if high methylfolate turnover) via THF mediated conversion of histidine into oxo-glutarate and then into glutamate as opposed to histamine (why overmethylators have low histamine). Glutamate in the CNS will bind to NMDA glutamate receptors.
I also have adrenal issues. A few years ago my cortisol tested and it was out of normal range (DHEA was normal). I don't know what these readings mean though:
CORTISOL - (1140) 5.5 (L) 13-24 nM (reference range)
CORTISOL - (1610) 24.0 (H) 5-8 nM (reference range)
CORTISOL - (2010) 1.9 (L) 1.9- nM (reference range)
Is that a 24 hour saliva cortisol test? Are the 1140, 1610, 2010 time points using military time (i.e. 11:40 am, 4:10 pm, and 8:10 pm)
If so then your numbers show dysregulation. Your peak is shifted by few hours. You have way too little in the morning. And too much in the afternoon. Did you follow all the instructions of the test correctly? Usually they would want you to take the first sample earlier in the day like 8-9 am and spread them further apart.
The heavy metal thing is actually very recent (3 months ago) so that could be a component since my symptoms got significantly worse after that. Since then, I'm sensitive to supplements related to ATP and methylation. I've read that among other things pregnenolone is depressed from mercury toxicity, but I'm sure that's only one of many things affected and I've had adrenal issues long before my amalgams.
I also have Lyme disease which would explain the immune aspect. There was a post by one of you that I've slowly been digesting which mentioned the immune system:
If you have Lyme's and the heavy metal things is only very recent then the Lyme's would seem to me to be a much bigger issue. But ,,, and this is a caution ... be careful since some LLMD way over-emphasize and toss antibiotics around when Lyme may not be the case. One doctor tried to push Lyme's on me which turned out to be total BS after suffering 3 months on high dose doxycycline (Lord the reflux) and good friend of mine went through a nightmare with a doctor who also pushed Lyme's but also turned out to be completely the wrong diagnosis. I would get careful second (and third) opinions before I jumped into treatment But if you do have Lyme's then it is a BIG deal. Everything else will be bandages until it is addressed but ONLY if it really is truly there.[/quote]
Prior to the late summer I did make a significant recovery. Although I think getting enough sleep and limiting my activities during the day were a huge part, I was taking a number of things related to ATP and Glutathione such as Vitamin C (4000mg/day), D-Ribose (10-15g/day), Magnesium (1000mg/day), Coenzyme Q10 (400mg/day), Acetyl L Carnitine (2000mg/day), Alpha Lipoic Acid (1200mg/day), NAC (1200mg/day), Reduced Glutathione sublingual (100mg/day), Selenium (300-400mcg/day), Molybdenum (300-400mcg/day), Glycine (4000mg/day), Glutamine (4000mg/day), Taurine (4000mg/day), MSM (4000mg/day), moderate amount of B vitamins (mostly non-active except a small amount of P5P and Methylcobalamin), Betaine HCL which I've read functions as TMG (800mg/day).
Let's see I take:
Vitamin C 6-8 mg (used to be ascorbic acid now sodium ascorbate).
D-ribose 10 g / day (used to be 15 g for about a year)
Magnesium 1000-1400 mg in various forms (though now I am thinking cutting back to 800 mg since turns out I excrete a lot)
CoQ10 used to take large amounts like 800 mg but turned out to be a major reflux problem -- currently on hiatus
Acetyl-carnitine - none, the 2000 mg you are taking can definitely antagonize T3 binding at the nuclear hormone receptors in both the CNS and the periphery, not something I would risk, my doctor forbids it for me
ALA -- took 600 mg / day for years, until I found out it was bad to take the racemic form, now ordering R-ALA
NAC - none since large doses make me mentally tired, also increases reflux in me, also not good for people with CBS problems, same with MSM
Reduced glutathione - none -- can help maybe liver and kidneys but body breaks all glutathione down into glutamate, cysteine and glycine to get in and out of cells where it is most needed, I find supplementing with rate-limiting amino acids and making sure ATP is high as possible and high vitamin C is the key with making glutathione (Rich Vank solved this for me)
Selenium - 200 mcg daily
Molybdenum - 450 mcg daily
Glycine -- you don't want to know how much
Glutamine 4 grams daily
Taurine 1-2 grams per day
TMG used to take 600 mg per day as betaine HCL or 500 mg at TMG tablets, no longer since was really raising my norepinephrine which I do not need ...
etc ...
So we have a lot of supplements in common