Hi dbkita!
Thanks for your interest, thanks for asking. Much appreciated.
I am heterozygous, sorry. That was the only genetic thing that was tested btw, so I don't know whether there are other issues as well.
(I am considering 23andme but I'm not at ease yet with them using my genetic info for other purposes.)
Other symptoms:
I consider fatigue the biggest issue at the moment, because it's turning me into an invalid.
Other things do not bother me every second of the day. But here they are:
Using the incorrect word without knowing it (e.g. yes instead of no, left instead of right) and persisting in that mistake when being confronted, mixing two fixed expressions into a new one, not being able to find the word I'm wishing to use, bumping into things (and e.g. breaking a nose as a result of it), tripping over nothing, not being able to walk in a straight line, shortnes of breath and rapid, uncomfortable pounding hearbeat when doing something small like combing my hair, muscle weakness (arms and legs feeling like they're made of lead, the staircase is a mountain to me), burning sensation under my skin after physical or mental exertion, jumping heart (missing a hearbeat), the feeling of (short painful) knife stabs in longs that take my breath away, feeling cold to the bone, sudden muscle contractions in legs/arms, or hands/calves (small and sometimes repetitive or big but one time only). And, remarkable but not complaining about: low heart beat (45-50), low blood pressure (< 100 and < 60) when not active.
In short: mostly b12 defciency symptoms I think.
My B12 was 119, at the time I did not supplement any B12.
My homocystein was slightly elevated (12.5).
I have been taking hydroxyB12 1 mg injections twice a week since being diagnosed b12-deficient. It did not help much, got worse actually. Started with the methylfolate, mB12 and aB12 pills in December 2012. Started with co-factors in January. Started with mB12 injections 1 mg thrice a week this week.
Sorry but many of those smack of something far different than B12 deficiency imho. Some of that sounds like electrolyte and Krebs cycle problems. But what you describe really smacks of hormonal problems possible secondary to immune system dysregulation.
I realize it is maybe too early to pass judgment on the mb12 and methyfolate protocols but so far no benefit to your fatigue, correct? And I would definitely suggest you continue with it.
But as for your symptoms ... I went through something similar to what you describe (though the low BP eludes me and was not one of my symptoms) in 2009. For me it was an autoimmune disease except in my case I had a ton of pain as well due to the specific nature of the autoimmune disease. That does not have to be your trigger but please be open to the idea that you may be facing something other than just b12 deficiency. I also do not believe a heterozygous MTHFR C677T is your main culprit ... not by a longshot. Have you had your thyroid and adrenal outputs checked? And I don't just mean TSH and cortisol btw ...
On the other hand is your serum sodium and potassium levels in range? What about magnesium and potassium RBC? Those muscle cramps, shortness of breath, and heart irregularities really suggest electrolyte imbalance assuming no underlying actual CV problem. Believe it or not the fatigue may be secondary to more primary problems. Methylation support can be a useful adjunct but if the other issues are not addressed it is unlikely to solve things.
Good luck and God Bless!