I myself 16 months ago took , among a massive amount of different supplements, ALA, chlorella, ashwagandha, B complex, minerals, ginkgo, gotu kola, all while having a damaged mercury amalgam filling in my mouth. I say damaged, because most of the filling and most of the tooth had been gone for 12 years, so it all essentially looked like a rotten tooth with out a filling. But trust me, it has pieces of amalgam concealed in the bottom of it. I have not recovered from this event, it caused me to aquire essentially chronic fatigue and anterograde amnesia. This is consistent with cutler forum warnings.
I take this to be the most outright empirical proof possible that ALA is as strong as it is, and that mercury causes highly specific, characteristic CFS symptoms. In fact mercury initiates most thyroid disease and B vitamin deficiency, because it plays a part in destroying your digestive capacity and consequential ability to absorb minerals like calcium, magnesium, zinc, and vitamins such as B-12. But the digestive inhibition will ultimately lead to mineral deficiency(in my case my hair test confirms 8 mineral deficiencies). This will shut down and limit the efficiency of most of the important biochemical synthesis cycles associated with the metabolism, production, and assimilation of a number of the B vitamins. This is one reason why thyroid disease, B vitamin deficiency, and mercury symptoms are similar.
Mercury plays a part in multiple chemical sensitivity and methylation concerns as well. However, according to cutler, mercury detoxification does not require correcting the methylation cycle. The downstream affect of this role means that as your toxic metal burden increases, you sequester more chemical toxins such as BHA, BPA, dioxin, etc.
I believe, and with poor knowledge to the public, that ALA is extremely dangerous in the wrong situations. I am currently still trying to learn by what means chemically it is responsible for somehow leaching mercury directly from an amalgam. Far fetched though it may be, it seems very certain to happen.