Hi;
The reason I increased mfolate again, was because, from what I've read about it, folate is predominately active with healing tissues. Methylcobalamin is reputed to be most active with healing nerves. But, I've also read that there is a crossover, and that each performs on both nerves and tissues.
One of the nagging symptoms I've had is canker sores. Since many people have healed theirs with extra folate, I decided to increase for that reason, in part. ( I tend to think that if I have lesions in the mouth, I may also have lesions elsewhere.)
In the past, I've tried increasing B2, zinc, lysine, herbs, and so on, because they also help with healing lesions of sorts. My cankers persisted.
I've also had to increase cortisol when they've become debilitating.
Now, it looks like methylcobalamin is the most effective substance for these lesions, in my case.
So, I believe it's really hard to separate the activity of each B vitamin.
But, when I took B complexes and individual B's for years without the sublingual methy-B12, none performed at all.
I did find that when I was taking such high dosages of methylfolate, I became hyper-sensitive to any extra folates, whether in supplements, or foods, naturally occurring, or fortified.
I've concluded that I was over-dosing Folate, in total, and my body had to give me a good slap to indicate as such.
In my case, I don't believe it was a paradox; it was a dire warning. " This is too too much."