I have around 4-5 amalgam fillings and I took 1200 mg/day Alpha Lipoic Acid for over a year without any problems. In fact, I improved during that time. I attribute most of my recovery to getting a lot of sleep and limiting activity, but I'm sure supplements help. I was also taking 1200 mg NAC, 100 mg Glutathione sublingual, 4000 mg MSM, 4000 mg Taurine, 300-400 mcg selenium and molybdenum. The reason I mention the other things is because they might have blocked any harmful effects if mercury was chelated. I just bought some ALA for my parents and now I'm kind of worried because they also have amalgams. I also read on the bottle that Alpha Lipoic Acid shouldn't be taken if you have a B-12 deficiency. I wasn't taking a high dose of B-12 and I don't think I had problems, but I really have no idea what sort of symptoms I would have experienced.