Summary of XMRV Research Studies
XMRV studies done in Germany, Ireland, UK, Japan and the USA.
German prostate cancer study #2
0/589 German prostate cancer patients XMRV 'Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients'
Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Denner J, Miller K, Kurth R, Bannert N. Retrovirology. 2009 Oct 16;6:92.
http://www.ncbi.nlm.nih.gov/pubmed/19835577
Irish prostate cancer study
0/139 Irish prostate cancer patients XMRV 'NO EVIDENCE OF XMRV IN IRISH PROSTATE CANCER PATIENTS WITH THE R462Q MUTATION'
D'Arcy F., Foley R., Perry A., Marignol L., Lawler M., Gaffney E.,Watson R.G.W., Fitzpatrick J.M., Lynch T.H. European Urology Supplements Volume 7, Issue 3, Page 271 (March 2008)
http://www.europeanurology-supplement.com/article/S1569-9056(08)60798-8/abstract
PLOS XMRV/CFS study
0/186 UK CFS patients XMRV 'Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome'
Otto Erlwein, Steve Kaye, Myra O. McClure, Jonathan Weber,Gillian Wills, David Collier, Simon Wessely, Anthony Cleare PLoS ONE 5(1): e8519 - Published: January 6, 2010
Original XMRV/prostate cancer study(US)
8/20(40%) prostate cancer patients XMRV+ and 1/66(1.5%) different kind
of prostate cancer patients XMRV+ 'Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant'
Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL. PLoS Pathog. 2006 Mar;2(3):e25. Epub 2006 Mar 31.
http://www.ncbi.nlm.nih.gov/pubmed/16609730
Replication XMRV/prostate cancer study(US)
334 consecutive prostate resection specimens- 62/233(27%) w/prostate cancer XMRV (XMRV DNA found in 6% and XMRV protein expression in 23%) vs. 6/101(6%) of cancer free controls XMRV , 'XMRV is present in malignant prostatic epithelium and is associated
with prostate cancer, especially high-grade tumors'.
Schlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16351-6.
http://www.ncbi.nlm.nih.gov/pubmed/19805305
5/300(1.7%) of healthy Japanese blood donors positive for antibodies to
XMRV 'The Prevalence of Xenotropic Murine Leukemia Virus-related Virus in Healthy Blood Donors in Japan'.
Furuta RA, Miyazawa T, Sugiyama T, Kimura T, Hirayama F, et al.
Cold Spring Harbor Retrovirus Symposium 2009
WPI XMRV/CFS study
68/101(67%) CFS patients and 8/218(3.75%) of healthy controls XMRV, 'Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome'.
Lombardi V, Ruscetti FW, Gupta JD, Pfost MA, Hagen KS, et al. Science. 2009 Oct 23;326(5952):585-9.
http://www.ncbi.nlm.nih.gov/pubmed/19815723
German prostate cancer study #1
1/105 non-familial prostate cancer patients and 1/70 tissue samples from men without prostate cancer XMRV, 'Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer'.
Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M,
Schlomm T.J Clin Virol. 2008 Nov;43(3):277-83.
http://www.ncbi.nlm.nih.gov/pubmed/18823818