Sherlock
Boswellia for lungs and MC stabllizing
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While looking for evidence as to whether the noted absorption-enhancer piperine would also enhance the absorption of quercetin, I found this paper which says that quercetin is itself a 'bioenhancer'. That's surprising because of how quercetin is said to be difficult to absorb - though maybe if quercetin is difficult to absorb then it stays in the gut and influences the absorption of other molecules.
http://www.ijabmr.org/article.asp?i...me=1;issue=1;spage=5;epage=10;aulast=Randhawa
Year : 2011
Bioenhancers from mother nature and their applicability in modern medicine
[piperine is in black pepper and even more-so in white pepper]
Also from that paper and of possible interest in POTS:
http://www.ijabmr.org/article.asp?i...me=1;issue=1;spage=5;epage=10;aulast=Randhawa
Year : 2011
Bioenhancers from mother nature and their applicability in modern medicine
Quercetin is found in citrus fruits and is a dual inhibitor of cytochrome P 3A4 (CYP3A4) and P-gp. Quercetin has exhibited a wide range of beneficial biological activities, including antioxidant, radical scavenging, anti-inflammatory, antiatherosclerotic, a...ntitumor, and antiviral effects. [30] In a study, pretreatment of quercetin (5.0 and 15 mg/kg) half an hour before verapamil (10 mg/kg) administration significantly altered the pharmacokinetics of verapamil. Compared with verapamil alone group, the Cmax and AUC of verapamil increased approximately two times in the rabbits pretreated with quercetin. Absolute and relative bioavailability values of verapamil in the rabbits pretreated with quercetin were significantly higher (P < 0.05) than verapamil alone group. [31] Similar results have been reported with pretreatment/co-treatment of quercetin with diltiazem, [32] paclitaxel, [33] digoxin, [34] doxorubicin, [35] and tamoxifen [36] [Table 2].
Table 2: Effect of quercetin pretreatment/co-treatment on pharmacokinetic parameters of different drugs
Click here to view
The relative bioavailability of paclitaxel after administration of the prodrug to rats pretreated with quercetin was 1.25-2.02-folds higher than the prodrug control. The development of oral paclitaxel preparations as a prodrug or with quercetin is feasible, which is more convenient than the intravenous dosage forms. [33]
[piperine is in black pepper and even more-so in white pepper]
Also from that paper and of possible interest in POTS:
but an association with the much more commonly used atenolol doesn't seem to show up.Piperine increases area under the curve (AUC) of... propranolol,