Anteah
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Thanks for that suggestion, Jeffrez! Which exactly long-term HPAA effects with PS are you talking about though? I didn't know it caused those, now kind of worried.
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A long time ago I had a RBC Zn test to rule out zinc deficiency causing bizarre symptoms after 20 sessions of IV CaEDTA treatment. However, I was already taking 40-80mg Zn (elemental) per day for about 6 weeks before the test but after cessation of said chelation treatments. The result was within normal range so I stopped taking zinc. Do you think I took enough zinc to interfere with the test? I still sometimes wonder if I have a zinc deficiency, unfortunately I seem to have developed a sensitivity to zinc even in relatively low doses.
Melatonin either keeps me awake or does nothing. Phosphatidyl does nothing. Are the herbs strong enough if taken as a tea? Are they taken at bedtime, or throughout the day?Have you tried melatonin, phosphatidyl serine, holy basil, schisandra or the like for the high cortisol at night?
I wouldn't think the herbs would be strong enough as a tea but I am not a seasoned herbalist. It would probably depend on how the tea was made and the quality of the raw product as well.Melatonin either keeps me awake or does nothing. Phosphatidyl does nothing. Are the herbs strong enough if taken as a tea? Are they taken at bedtime, or throughout the day?
Thanks for that suggestion, Jeffrez! Which exactly long-term HPAA effects with PS are you talking about though? I didn't know it caused those, now kind of worried.
One way to check for zinc deficiency is to look at the activity of alkaline phosphatase, which is on the standard blood metabolic panel that physicians routinely run, used as one of the markers for liver function. This is a zinc-requiring enzyme, so if its activity is much below the mean value of its reference range, it suggests zinc deficiency. If not, the zinc level is probably O.K.
Best regards,
Rich
This is so interesting!
So by mean value, do you mean 50% of the reference range or about 88 (25-150)?
I've been testing for zinc, serum and RBC and trying to work out if I have a deficiency. By this test, with an alkaline phosphatase value of 57, that would certainly be in line with a deficiency if I am understanding correctly?
Thanks!
I thought about taking P5P for cognitive function (concentration/attention) but as far as I understand, lower the cortisol while adrenal glands are weak isn't such a good idea.P5P, the active form of B6, can lower cortisol. P5P also won't be likely to have the long-term HPAA effects that PS can have.
Sorry, I know of no reason to be picky about zinc or brands...I have on my shelf this right now:I agree, triffid, same here, I have severe anxiety as a reaction to milk products, and feeling of adrenal burn out. Zinc though is somewhat of a issue for me, I can take up to 75mg a day but more just give me constipation, and I take magnesium and eat a lot of fiber, so you'd think it would counteract it but it doesn't for some reason. What form of zinc do you use?
I may have already said this, but DHEA lowers cortisol (or I should say, normalizes cortisol). However DHEA is used up in the case of illness, so you can still get adrenal burnout...just not as fast. I get adrenal burnout 3 weeks into a 4 week long allergy season (DHEA manages to hold it off until then). Life EXtension advocates using DHEA to treat flu. Coffee raises cortisol (2 cups, 33%) and after I turned 50 I could not drink coffee at all (caused panic attack as well as raised blood pressure) until I supplemented DHEA. Now I can drink it again.I thought about taking P5P for cognitive function (concentration/attention) but as far as I understand, lower the cortisol while adrenal glands are weak isn't such a good idea.
Does the basic B-6 also has a potential to lower cortisol? It is one of the components of B-complex (0.5 mg in 1 drop in my B-complex), that is very recommended for adrenals supporting.
Hi, Ema.
Yes, that's right. Looks as though your zinc is somewhat low. Do you have white spots on your fingernails? That's another indicator of low zinc, though I'm not sure it is as reliable.
Best regards,
Rich
I may have already said this, but DHEA lowers cortisol (or I should say, normalizes cortisol).
P5P, the active form of B6, can lower cortisol. P5P also won't be likely to have the long-term HPAA effects that PS can have.
I'm not sure that P5P or B6 lowers cortisol.
Here is a summary of the research from LiveStrong:
B-6 and Cortisol
A study linking the relationship between cortisol and vitamin B-6 was published in 1960 in the journal "Endocrinology." At that time, researchers discovered that rats who had depleted levels of vitamin B-6 experienced reduced cortisol action. These results suggested that B-6 is actually essential to how cortisol functions and does not inhibit its actions. Further support for this research was demonstrated in 1984 in an article published in the "Bulletin of the Italian Society of Experimental Biology." Italian researchers studied the effect of vitamin B-6 on circadian rhythm, ACTH and cortisol in humans. The results revealed that supplementation of vitamin B-6 had no effect on ACTH or cortisol. To date, no studies have proven otherwise. Although vitamin B-6 plays a role in the production of enzymes closely linked to cortisol, supplementation does not reduce its effects.
Read more: http://www.livestrong.com/article/523976-does-vitamin-b-6-lower-cortisol/#ixzz21B0iPbGq
I generally agree with your assessment of LiveStrong but the summary is pretty good in this case in my opinion and points towards the actual research articles for those who wish to look into it further.That's interesting, but I wouldn't really trust anything I read on Livestrong. Their info tends to be spotty & incomplete at best, in my experience. Pretty sure that P5P antagonizes steroid activity, whether through directly lowering cortisol levels or the effects through receptors, binding, etc.