Hi Triff,
many thanks for your reply!
The bad thing is that it seems to have not only destroyed methylation (if at all the cycle was running...), but also it and primarily the Glutathione seem to have relocated critical amounts of mercury which seemingly used to be stored "safely" somewhere in my belly and brought it into my head and the CNS...
I still have strong symptoms of CNS irritability: mostly nerve pain in my back and head (ears, teeth), headache/tinnitus, slight tremors, and muscle twitching at almost any location in regular intervals.
After having done some more lab work ordered by my doc, I will therefore start the Cutler protocol using 25 mg of DMSA (due to my body weight - 240 lbs) every 4 hours on Thursday and truly hope that this will help about these symptoms...
Does the need for a "cancer avoidance strategy" also apply to DHEA?
I am also taking 50mg every morning, but I cannot really say that they help regarding my COMT Met/Met related anxiety/agitation...!?
I am also already taking 50mg of P5P (evenly divided between morning and evening), but can definitely try to go to 100mg. Regarding Trimethylglycine, I did not know that this exists until now. My doc had prescribed ordinary Glycine, but I left this out recently due to the fact that I did not feel any difference from taking it. Should TMG work better? If it is a methyl group donator, it might make me even more anxious and agitated like SAMe does (probably also due to CBS and/or SUOX issues which have not yet been looked at)...
My doc and I decided to stay away from 5-MTHF for now at least, as we just got the lab news back that I only seem to have a neglectable MTHFR issue (MTHFR A1298 = AC), and wait and see how my body will be able to cope with the Cutler protocol (while still continuing with Levaquin)...
Thanks again for your kind help & BR,
awl29
many thanks for your reply!
Freddd has not been in I see. I just want to say that he would tell you that NAC can completely destroy methylation in many people, including himself and it can take moths (like 6 months) to restore it. Fredd will have to tell you detail this is only ballpark. I would never take it.
The bad thing is that it seems to have not only destroyed methylation (if at all the cycle was running...), but also it and primarily the Glutathione seem to have relocated critical amounts of mercury which seemingly used to be stored "safely" somewhere in my belly and brought it into my head and the CNS...
I still have strong symptoms of CNS irritability: mostly nerve pain in my back and head (ears, teeth), headache/tinnitus, slight tremors, and muscle twitching at almost any location in regular intervals.
After having done some more lab work ordered by my doc, I will therefore start the Cutler protocol using 25 mg of DMSA (due to my body weight - 240 lbs) every 4 hours on Thursday and truly hope that this will help about these symptoms...
I have Two COMT +/+ genetic mutations and I never get hypermethylation. This may be because I have genetic difficulty making BH4 to begin with, no idea. However I will tell you that I would have anxiety 24/7 and be unable to function if I did not take DHEA, which banishes it in under 15 minutes. I take 75mg DHEA in a divided dose to be right with the world and 30mg pregnenolone. I do not suggest you do the same as this is a very individual doe that works for me. Freddd used to take 100mg pregnenolone and 25mg DHEA, which is more normal. As we all fine tune our protocols, I dunno if he still takes it in that amount. This is hormone replacement, however, and I would read all they have to say about hormone replacement at www.lef.org and come up with a cancer avoidance stratgey (as I did) before I embarked on any such supplementation regime.
Does the need for a "cancer avoidance strategy" also apply to DHEA?
I am also taking 50mg every morning, but I cannot really say that they help regarding my COMT Met/Met related anxiety/agitation...!?
If I had an episode like yours, I would be taking P5P and TMG to try to clear the log jam. In my own personal case it does not seem that taking 200-300mg P5P is any more effective in lowering homocysteine than 100mg P5P so I think that pathway (at least in me) can only go so fast (but I would take the 100mg P5P) and then I would take 2g TMG to clear the backup. I would tend to take extra TMG if symptoms persisted. I know it sounds crazy because TMG helps you make SAMe. But listen to this...lyme uses up your MB12 and when you replace the mB12 with hydroxycobalamin you simply may not have the methyls to convert hydroxy to mB12 (the only form your body can use) and you may just be accumulating homocysteine with nowhere to get rid of it, which is a feedback to the methyl cycle affecting methylation btw. I would want to clear it out and the only way to do that is to make sure you are getting as much P5P as your body can use (I have several CBS +/+ mutations so I can't use P5P any faster than 100mg/day apparently but maybe you can), and TMG to supply methyls to turn hydroxyB12 to mB12 and also to get rid of the backup of homocysteine through the BHMT pathway. *I* think if you clear up the log jam, it will help you feel better. That is what I always do when I have a problem and it works for me.
I am also already taking 50mg of P5P (evenly divided between morning and evening), but can definitely try to go to 100mg. Regarding Trimethylglycine, I did not know that this exists until now. My doc had prescribed ordinary Glycine, but I left this out recently due to the fact that I did not feel any difference from taking it. Should TMG work better? If it is a methyl group donator, it might make me even more anxious and agitated like SAMe does (probably also due to CBS and/or SUOX issues which have not yet been looked at)...
Of course to get the protocol to work you do need mfolate. But your question was how to clear up the "all hell breaks lose" and I think you have to clear up the log jam to do that. I do not know how cysteine plays into that, I mean how you can neutralize taking NAC (maybe not possible). But I do have experience with my own very broken genes, clearing methyl cycle log jams. It may help you as it does me. At worse it will clear homocysteine but not clear your symptoms (in other words it can only help even if you can't tell it's helping).
My doc and I decided to stay away from 5-MTHF for now at least, as we just got the lab news back that I only seem to have a neglectable MTHFR issue (MTHFR A1298 = AC), and wait and see how my body will be able to cope with the Cutler protocol (while still continuing with Levaquin)...
Thanks again for your kind help & BR,
awl29