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Hi,
I see on various threads that people are taking 800 mcg of L-Methylfolate everyday,with B-12 sublinguals. I am from India and here I can just find Deplin(7.5mg) which is available. Is it safe to take 7.5mg of L-Methylfolate everyday?
Also, what percentage of folic acid is converted to l-methylfolate?
I understand that it differs from person to person,but just a rough estimate will be enough.
Metafolin methylfolate is only allowed to be sold in dosages of 800 mcg or less (or maybe 1000 mcg?) which is why he has it listed as only 800 mcg since that's the largest available, but Freddd actually recommends much higher dosages than 800 mcg. In Freddd's most recent protocol revision (as far as I know) he lists methylfolate dosage from 800-16,000 mcg. (that's not a typo it's up to 16 thousand mcg)HI all .
just one question on dosage of L-Methylfolate .
Why so big difference between dose of Rich protocol (200 mmcg/day) and Fredd protocol (800 mcg/day) ?
Thanks
Daniele
This is a buffer form of folate that most people can readily convert to other active forms of folate. Its role in the protocol is to supply these other forms while the methionine synthase reaction has still not come up to normal. This is particularly important for making new DNA and RNA for replacing cells.
I had also considered changing the form of B12 to methylcobalamin. Some PWMEs do need to use this form, particularly if their glutathione and/or S-adenosylmethionine are very low. However, use of hydroxocobalamin is a “gentler” approach to lifting the partial methylation cycle block, and many PWMEs need such an approach. Use of hydroxocobalamin also keeps the cells in control of the rate of the methylation cycle, preventing it from being overdriven, which slows the rise of glutathione. So I have decided to stay with hydroxocobalamin as the first form of B12 to try. For people who do not get a response from the SMP within a couple of months, switching to methylcobalamin would be an option to try. Another option would be to try adding some adenosylcobalamin (dibencozide). However, I do not favor raising the overall dosage of B12 very much above 2,000 micrograms per day, and especially not when it is combined with dosages of methyfolate that are much above the RDA range of 400 to 800 micrograms per day. This combination can overdrive the methylation cycle and hinder the rise of glutathione.
Best regards,
Rich