Adreno- So it our homostasis is off? Our bodies have a great deal to balance out but there has to be some effective treatment to overide this process. I know it controls our tempeture and some other stuff but I think it is time to pull out my human physiology notes.
For adaptive reasons, our bodies have maneuvered into a set point, or biological configuration if you will, that is different from the biological set point of healthy people. Nevertheless, our bodies will strive to maintain this set point.
We can measure different kinds of biomarkers associated with this disease (such as low cortisol levels for instance), but that doesn't mean that these abnormal biomarkers are causative, or that normalizing them will lead to remission. The biological changes might very well be adaptive (compensatory). For example (and I am just guessing here), cortisol levels might be lowered in ME patients, because this will allow the immune system to fight viral infections more effectively. So if you then take any substance that artificially increases cortisol levels, the body will do everything it can to bring the levels down again. You might experience increased cortisol levels for a while, but usually your body will then compensate.
Likewise, the feeling of fatigue and malaise that accompanies ME are probably what is known as "sickness behavior", instructing you to rest, so that your immune system can work optimally, and you don't induce any further damage. This is similar to pain, which is a feedback signal instructing you to stop or change some behavior, as it is causing you damage. You could override the pain and fatigue by taking amphetamine, but likely this will only make you worse in the long term.
The upshot is that normalizing biomarkers is not likely to work in the long term. You need to find and correct the root cause(s) that induced the adaptive changes in the first place. In this sense I agree with nanonug; if you have a chronic infection going on (and I am not saying this is the cause of ME), then your biological values (set point) will never return to normal until the infection is controlled.