**Hi, steelfan.
You don't appear to have serious gut dysbiosis, but it looks like you have a yeast overgrowth.
*****I've been taking Candex and have finished 1 and 1/2 bottles at a strength of 4 per day. Thrash on my tongue has gone way down in the past week.
**That's good to hear!
You have low flow from pyruvate to the citric acid cycle, which could be due to low B-complex vitamins, low magnesium, and/or low lipoic acid.
*****I just started a b complex a few weeks ago. I ordered some magnesium oil and will start using it when it arrives, hopefully tomorrow. Lipoic acid = Vitamin C?
**O.K. No, lipoic acid is sold as either alpha lipoic acid or R-lipoic acid. The latter contains only the form that the body uses. It costs more, but is probably better.
Your body is mobilizing fatty acids, but having trouble getting them into the mitochondria and burning them. Could be low carnitine or low B2 or both.
*****Suggest taking these separate?
**You could add some carnitine, maybe as carnitine fumarate. Freddd finds that form to be very helpful. I think Amy Yasko does, too.
Your citric acid cycle is running pretty slow because it isn't being fed fast enough, which would give you an energy deficit.
*****Is this something that will improve with the protocol?
**It should be covered by the stuff discussed above.
Your succinic acid is below the detection limit, indicating that you aren't burning amino acids as fuel at a normal rate. This is likely due to low B2, low B6, and/or low biotin.
*****B2 seems to be coming up as an issue. Recommend taking this separate? In niacin form?
**I think you will get enough in the B-complex. Niacin is B3. Riboflavin is B2.
Your neurotransmitter metabolites are low, probably due to low B2 or low B6 or both. Your tetrahydrobiopterin is likely low as well, because of the low status of the folate metabolism, which is linked to the biopterin cycle.
*****Again B2 and B6 rearing their ugly heads.
**Yes, they are pretty vital, and when they are low, many parts of the metabolism suffer.
The second through the fourth vitamin markers are high, indicating low B-complex vitamins or low lipoic acid, or both.
*****If lipoic is vitamin C, I just started liquid C from Let's Talk Health.
**Discussed above. Vitamin C is ascorbic acid. It's good stuff, too, but I don't recommend going above 2 grams per day if glutathione is depleted, because it will place demands on glutathione for its recycling.
Your Figlu is high, indicating low tetrahydrofolate, which is also consistent with your high sarcosine on the amino acids panel. The low THF indicates that there is a partial block in methionine synthase, which links the folate metabolism with the methylation cycle, and that your folates have become depleted.
*****Running the protocol will help with this?
**Yep.
Your 3-hydroxyisovaleric acid is pretty high-normal, indicating low biotin.
*****Biotin coming up again. Recommend supplementing?
**It should be in the B-complex.
Your first two detox markers indicate that you have been exposed to styrene (as from polystyrene cups, for example) and MTBE (from gasoline fumes), and your detox system is not working very well.
*****Will my system hopefully detox these things as I raise glutathione?
**Yes, I think it will.
The low orotic acid in the presence of high ammonia (on the amino acids panel) indicates magnesium deficiency.
*****Mag oil on the way.
**Bravo!
The low pyroglutamic acid indicates glutathione depletion, which is consistent with the total RBC glutathione level (later). Low B2 could be contributing.
*****Again, B2.
**Yep. It is important for recycling glutathione. And the methylation protocol should help the production of glutathione.
The abnormalities in your amino acids that haven't already been discussed appear to be due to low B2 or B6 or both.
Your omega-3 fatty acids intake looks O.K. Must be getting some fish oil.
*****Taking 1gm of omega-3 fatty acids a day.
**O.K.
Your intake of monounsaturated fatty acids (omega-9) appears to be low. Must not be getting much olive oil.
******Started using macadamia nut and olive oil.
**O.K.
Looks like you must be eating meat, but not many peanuts.
I'm surprised that your oxidative stress markers are not elevated, given your low glutathione. Maybe you are taking in other antioxidants.
*****Not taking other antioxidants.
**O.K., well, that's a puzzle then.
You do have some low minerals: copper, magnesium, potassium and selenium.
*****Started 200mg selenium at night.
**O.K. You could double that.
Your RBC toxic elements don't look too bad. You could have toxic elements stored in your tissues from exposures in the past, though, because some don't stay in the blood very long.
I guess that's it. The methylation protocol will probably help you, but I think you will need to build up some of the deficient vitamins and minerals in order to get this part of the metabolism working at a normal level again.
Best regards,
Rich
Shew, that's a lot of stuff.
Thanks Rich!
**You're welcome. I expect that you will be a regular Superman before long, now that you are fixing all these issues!
-)
**I do wish you the best.
**Rich