You completely misunderstood what I said so not sure I can clarify it further now that you're clearly feeling defensive. I was not saying, in ANY stretch of the imagination, that in having the 23&me test done that it challenges anyone on anything. I'm merely pointing out that when you make comments about how the Yasko panel doesn't take into account many other genes, its sorta arm chair quarter backing without having the education or background to do so. I checked those spreadsheet rs #s with 23&me AND my doc and unless you have some inside track as to what Yasko uses for her rs #s for things like the BHMT for instance, you cannot assert with 100% accuracy that they translate to 23&me. Especially when they are not using the established standard. So, I would have to turn the tables on this one and say that everything you've said falls under question. Especially since my doc said that many on that sheet are obsolete and don't match what Yasko uses. I'd really be careful about what you claim as fact because its not fair to those using it as the gospel to recover. I have used Prometheus as well and again, they don't use the same rs #s Yasko uses so you either know someone on the inside track over there or your still making guestimates.
You also admit to being a very broken person so I find it odd that you adamantly stick to Your claims despite this while I, along with 30 people in my biomed group, are on the road to recovery? Perhaps it is a shame that I don't properly know how to navigate the entire 23&me site, as you've implied, spending 100's of hours in the process but you see, I prefer spending that time on actually recovering.
I don't have a problem with anyone using 23&me as an adjunct but some seem to feel it is the end all and that spending an infinite amount of time reading about intriguing, yet in the end, unhelpful data is not exactly my idea of getting anywhere, its merely interesting. I don't know about you, but we're not all officially disabled and allowed to collect FundsI so some of us have to get on the ball rather than researching intersting topics for the next decade. I don't begrudge anyone their Disability payments either, I congratulate you! Ifanyone understands how impossible it is to work, its someone like me who was bedridden for over a year. But you see, as intruguing as geneology may be, I aim to get better and better. I'm certainly not here studying for my geneology doctorate. I'm glad you have the time to do so but it also just might be better spent on more targeted treatments. Like your potential CBS and /or maybe ACE defect, for starters. This is commonly seen with POTS. I know mine resolved, along with many others by using such "limited" tactics. Yet I do realize that there are other factors involved. I just find it perplexing that the sickest people on this site, the ones who haven't shown much evidence of recovery, are the most tenacious regarding 23&me? Seems odd.
We agree on one thing at least, no one gene is responsible for everything. However, if you truly understand methylation, you would know that you can have a billion genes and certain biochemical areas are in charge of turning them on or off. I've personally found this to be true as have a minimum of 50 of my biomed group, friends, family, and even neighbors. So I guess my major flaw is that I like to see results. I guess we can't all be perfect.
Angela
Sorry Greenshots, but there are just so many inaccuracies and assumptions in your posts, so I have to question everything you are writing now. I don't quite understand how getting the 23andme testing done is questioning Yasko or in some way an affront to you? If you don't want to use your 23andme results to their highest potential that is fine and I'm not twisting people's arms to get this test done. I've been wanting to get this test done for years before I even knew who Yasko was. They test for a lot of other important things besides the more fluffy health traits. (carrier status, P450 liver pathways, other random SNP's of importance...). Have you run your data through Promethease? How about these 3rd party tools? Are you at all interested in genealogy?
It's unfortunate you do not know how to navigate the website to get the most of your data besides what is listed in the health reports on the website. It is admittedly a bit confusing at first and it takes time understanding where to even start looking.
I think it's great Yasko is looking for more genes. Whenever she finds them there's a good chance I'll already have the SNP's covered by 23andme. She just recently removed a few SNP's and added CBS N212N and I was glad to see 23andme had already been reporting on that one. It's a shame those who got tested with Yasko won't know what their results are for this one unless they spend more money. It sounds like those with 23andme data may be in a better position than someone who just got the 30 SNP's from Yasko herself. I also felt the cost is a bit much considering how little you get from Yasko, but that's just me. I'm a very broke sick person. lol
I don't think there is one gene out there that is the answer at all. That seems pretty clear considering how we all respond to different treatments and how our symptoms are different too. I for one do not have CFS, but I do have severe POTS or OI. I do believe some people are going to find out they have a rare variant in their 23andme data that may be causing A LOT of issues though. I found out I have a lot mutations on my P450 liver pathways. I also found out I carry an allele where I cannot take certain types of anti-epileptic medications without suffering from severe side effects. These are all things Yasko are not testing for at all.
Unfortunately you have made a lot of assumptions of me based upon a few posts here. The reason why I made the spreadsheet was because I was confused in how to translate the data into "Yasko speak". The reason for getting the test was not for the methylation SNP's at all. That was just a nice added bonus. Yasko uses a very weird notation in order to allow people to see and discuss their results and I wanted everyone who got 23andme results to be able to participate in the methylation discussions. Surely allowing more people to use the data available out there to make themselves better with Yasko's protocol is only a good thing.
I think it's a shame that you do not want people to research further into their own illnesses. Surely people are free to do whatever they like to do and it is our unique input and experiences that make these forums what they are. We can talk theories all day, but I want to know what people are actually getting out of them.
greenshots said: ↑
Also, I would like to know how you can confirm with 100 accuracy what the BHMT 1, 2, 4, & 8 are in correlation to 23&Me's rs numbers? I do believe someone went through and maybe made some educated guesses that everyone is now using as hard fact. But I don't like to rely on guesses so if your absolutely certain of these correlations, please cite where this data is plainly stated. I would love to have them for my mother.
Regrettably, I've already seen that spreadsheet and some of the rs #'s are either obsolete or inaccurate. When I see Dr. Vank support these, I will jump in 100% but I haven't seen him say one word about the results being on the nose either and I think he probably would if they were right. But maybe I'm wrong and someone has him discussing this somewhere here. God knows I've searched my fingers to the bone looking and come up empty.
If you got your results done last fall and used a spreadsheet back then, then you were using another person's spreadsheet. I had seen that one and found it very hard to follow, so I created my own just last month. Can you point out specifically which RS ID's are "obsolete or inaccurate" because I want the accuracy of this to be 100%. I looked them up myself and for most I have the links to the sources where the rs Id's were listed in studies.
Are your results for BHMT from 23andme different from what Yasko has reported? Is there some other reason you are questioning their accuracy? I have heard from others who got both done that everything matched up perfectly for them. However if this is not the case for you, then putting inaccurate info out there is no my intent at all and that is why I have listed my email address directly on the spreadsheet for people to contact me.
