Persimmon
Senior Member
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This is an attempt to summarise the status of current and prospective clinical trials of Rituximab as a treatment for ME/CFS:
Fluge & Mella - phase II - Under way
- This open-label study is testing alternative dosage protocols.
Fluge & Mella - phase III - Not yet underway
- This is to be a large sample, double-blinded placebo-controlled study;
- They have substantial funding from the Norwegian government, but are currently trying to raise additional funding;
- This study is likely to utilize the findings from their current study (see above), and so isnt likely to commence until they are at least 6-9 months into that current study;
- Publication is probably 3 years away.
Spanish researchers - ?? - Under way ??
Dr Derek Enlander has stated a desire to conduct a replication study in conjunction with Dr David Bell, but they would have to raise the funding first (ie they'd be trying to replicate the findings of Fluge and Mella's 2011 publication).
Dr Andy Kogelnik is currently treating some ME/CFS patients with Rituximab (off-label), and is said to be expecting to have a formal clinical trial running by the end of 2012. He's proposing to treat patients with the combination of Rituximab and an antiviral. He's been trying to get this trial going since 2010.
Dr Klimas might also be trying to arrange a study.
Any corrections and additional info would be welcomed
[THERE IS AN UPDATE VERSION OF THIS SUMMARY BELOW (thread submission #8)]
Fluge & Mella - phase II - Under way
- This open-label study is testing alternative dosage protocols.
Fluge & Mella - phase III - Not yet underway
- This is to be a large sample, double-blinded placebo-controlled study;
- They have substantial funding from the Norwegian government, but are currently trying to raise additional funding;
- This study is likely to utilize the findings from their current study (see above), and so isnt likely to commence until they are at least 6-9 months into that current study;
- Publication is probably 3 years away.
Spanish researchers - ?? - Under way ??
Dr Derek Enlander has stated a desire to conduct a replication study in conjunction with Dr David Bell, but they would have to raise the funding first (ie they'd be trying to replicate the findings of Fluge and Mella's 2011 publication).
Dr Andy Kogelnik is currently treating some ME/CFS patients with Rituximab (off-label), and is said to be expecting to have a formal clinical trial running by the end of 2012. He's proposing to treat patients with the combination of Rituximab and an antiviral. He's been trying to get this trial going since 2010.
Dr Klimas might also be trying to arrange a study.
Any corrections and additional info would be welcomed
[THERE IS AN UPDATE VERSION OF THIS SUMMARY BELOW (thread submission #8)]