On the website he says that Merck doesn't allow anymore than 1mg of metafolin in any product:
http://mthfr.net/metafolin-knock-offs-caution/2011/11/17/
Is this really true? How about prescription drugs?
Then somewhere he talks about racemic methylfolate, and the D isomer being bad. But Thorne's product is L-5-MTHF, so I'm not worried.
He also disagrees with a lot of your theories. I suggest you read this:
http://mthfr.net/taking-folate-and-feeling-badly-methylation-requires-balance/2011/11/15/
If he is right, then I am somewhat worried about what we're doing here.
Hi Adreno,
There is a reason that Merck doesn't allow more than 1mg of Metafolin in OTC vitamins. First, there are laws in some countries that would prevent that. Second, there are contractual obligations with the companies developing prescription products to protect their hundreds of millions of dollars of cost in developing and testing prescription items.
He also disagrees with a lot of your theories.
That's good. It produces a vigorous intellectual enviromment. It was after the Bay of Pigs fiasco that the term "groupthink" was coined. He clearly does not see either the lower potassium or the effect of a low dose of Metafolin with enough mb12 able to start so much methylation that a small dose of Metafolin can't maintain it. He needs more experience. He doesn't have the mb12 and adb12 experience. There have been zero controlled studies documenting these things that we are just recognizing in these past few days. In the past months my ideas about Metafolin have turned over so many times it might as well be on the spin cycle.
If he is right, then I am somewhat worried about what we're doing here
However, people here have already done what he is saying and moved on by learning more. He is also narrowly focused on genes and the theory arising there and appears to lack the quantitiy and breadth of experience that we have here collectively.
Also, looking at the specific item, this may be the effect of taking the methylfolate without the mb12 increasing the subacute combined degeneration or CNS symtpoms that I have been warning about lately. It is the exact same old warning about not taking folate without b12 in a slightly different form. Again, he appears to not have as much experience and doesn't recognize these various effects and my not even be aware of them.
You have just worked your way through about 5 or more generations of what would be studies taking a 5 year cycle each to work through and have determined for yourself that you do MUCH better on the higher dose of methylfolate. I would suggest that you let yourself become stable in in before trying the other methylfolate so you will know what the effects are more clearly.
Speaking of that, while it is still clear in your mind, exactly what symptoms cleared up with the larger dose of Metafolin.
Many of the symptoms he mentions in terms of "too much methylfolate" are a combo of paradoxical folate deficiency, low potassium especially and maybe other induced deficiencies. He is also speaking as high as 50mg of methylfolate.