PokerPlayer
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- Seattle, Washington
So I have done a bit of reading and trying to put all the pieces together.
In short, I think my cfs looks very similar to a lot of peoples, but my underlying reason for it is much different. I think my underlying reason is the kindling theory. My multiple frontal lobe concussions have caused a brain that is hyper sensitive and causes overstimulation, causing me to feel wired and exhausted. I think it comes down to NMDA receptor issues and excitotoxicity.
NMDA and excitotoxicity possibly explain every single reaction I have to supplements, and even meditation! Thats right, remember me posting about medition causing increased anxiety/depression? Well it is hypothesized that deep meditation can activate the nmda receptors and raise serotonin. Too much serotonin in a sensitive brain = excitotoxicity.
Even vitamin d calms down excitotoxicity http://www.jneurosci.org/content/21/1/98.full.pdf , and that is its main mechanism of action in raising my crash tolerance. Remember, in me, anything that causes brain fog/brain slow down = calm mood, increased physical crash tolerance, no depression, but downside is a fogged out apathy.
Folic acid is also thought to modulate the nmda receptor http://www.ncbi.nlm.nih.gov/pubmed/18789921
Methyl b12 reduces nmda excitotoxicity http://www.iovs.org/content/38/5/848.full.pdf+html
A big question I have though, is why have I gotten to the point where I feel nothing when I take folic acid, b12, and vitamin d? I recently just crossed a threshold where they do not cause brain fog or anything, its like taking a sugar pill. It seems as though my current excitotoxicity state is too much for these natural remedies.
I am going to a doctor appointment in an hour and the doctor previously recommended gabapentin but I declined at the time because I wasn't depressed or anxious, just foggy. I am also going to talk to the doctor about klonopin. I am very curious as to what my reactions to gabapentin and klonopin could be.
I also found this little article on Head injuries and kindling excitotoxicity causing cfs. But it seems like a lot of things I read that don't work, with too much certainty to the theory. http://www.ncf-net.org/forum/neurontin98.htm
In short, I think my cfs looks very similar to a lot of peoples, but my underlying reason for it is much different. I think my underlying reason is the kindling theory. My multiple frontal lobe concussions have caused a brain that is hyper sensitive and causes overstimulation, causing me to feel wired and exhausted. I think it comes down to NMDA receptor issues and excitotoxicity.
NMDA and excitotoxicity possibly explain every single reaction I have to supplements, and even meditation! Thats right, remember me posting about medition causing increased anxiety/depression? Well it is hypothesized that deep meditation can activate the nmda receptors and raise serotonin. Too much serotonin in a sensitive brain = excitotoxicity.
Even vitamin d calms down excitotoxicity http://www.jneurosci.org/content/21/1/98.full.pdf , and that is its main mechanism of action in raising my crash tolerance. Remember, in me, anything that causes brain fog/brain slow down = calm mood, increased physical crash tolerance, no depression, but downside is a fogged out apathy.
Folic acid is also thought to modulate the nmda receptor http://www.ncbi.nlm.nih.gov/pubmed/18789921
Methyl b12 reduces nmda excitotoxicity http://www.iovs.org/content/38/5/848.full.pdf+html
A big question I have though, is why have I gotten to the point where I feel nothing when I take folic acid, b12, and vitamin d? I recently just crossed a threshold where they do not cause brain fog or anything, its like taking a sugar pill. It seems as though my current excitotoxicity state is too much for these natural remedies.
I am going to a doctor appointment in an hour and the doctor previously recommended gabapentin but I declined at the time because I wasn't depressed or anxious, just foggy. I am also going to talk to the doctor about klonopin. I am very curious as to what my reactions to gabapentin and klonopin could be.
I also found this little article on Head injuries and kindling excitotoxicity causing cfs. But it seems like a lot of things I read that don't work, with too much certainty to the theory. http://www.ncf-net.org/forum/neurontin98.htm