Here is my current list of the abnormalities found in ME/CFS that I believe can be explained by the Glutathione Depletion--Methylation Cycle Block hypothesis:
1. Glutathione depletion
2. Oxidative stress
3. Alcohol intolerance
4. Buildup of toxins
5. Multiple chemical sensitivities
6. Shift to Th2 immune response
7. Failure of T lymphocytes to proliferate when stimulated by mitogens
8. Persistence of RNase-L activation and cleavage to form LMW RNase-L
9. Reactivation of viral and intracellular bacterial infections
10. Accumulation of infections over time
11. Lymphadenopathy
12. Low or dysregulated secretion of some peptide hormones.
13. Misfolding of proteins
14. Disruption of the sleep-wake cycle
15. Deficiency of perforin secretion
16. Depletion of intracellular magnesium
17. Muscle twitching
18. Mitral valve prolapse
19. Blunting of the HPA axis
20. Sensitivity to stress
21. Panic attacks
22. Hypoglycemia
23. Low blood pressure
24. Low secretory IgA
25. Mitochondrial dysfunction
26. Low VO2 max
27. Hypocapnia
28. Low peripheral body temperature
29. Fatigue and post-exertional exhaustion
30. Weight gain and weight loss
31. Low serum amino acids levels
32. Shortness of breath
33. Weakness
34. Elevated methylmalonate
35. Elevated homocysteine
36. Parasthesia, neuropathy
37. Elevated formiminoglutamate
38. Low WBC
39. Low RBC
40. Elevated MCV and MCH
41. Deficits in synthesis of creatine, choline, carnitine, coenzyme Q10 and melatonin
42. Rise in histamine
43. Neurotransmitter abnormalities
44. Emotional lability
45. Excitotoxicity (anxiety, nervousness, insomnia, sensory sensitization)
46. Myelin disrepair
47. Slow mental processing speed
48. Electromagnetic hypersensitivity
49. Diastolic dysfunction and low cardiac output
50. Diabetes insipidus (polyuria, constant thirst)
51. Low total blood volume
52. Orthostatic hypotension and POTS
53. Loss of temperature regulation
54. Low stomach acid production
55. Slow gastric emptying and GERD
56. Bacterial dysbiosis, yeast infections
57. Irritable bowel syndrome (bloating, abdominal pain, diarrhea, constipation)
58. Leaky gut syndrome
59. Food sensitivities
60. Hashimotos thyroiditis
Best regards,
Rich
1. Glutathione depletion
2. Oxidative stress
3. Alcohol intolerance
4. Buildup of toxins
5. Multiple chemical sensitivities
6. Shift to Th2 immune response
7. Failure of T lymphocytes to proliferate when stimulated by mitogens
8. Persistence of RNase-L activation and cleavage to form LMW RNase-L
9. Reactivation of viral and intracellular bacterial infections
10. Accumulation of infections over time
11. Lymphadenopathy
12. Low or dysregulated secretion of some peptide hormones.
13. Misfolding of proteins
14. Disruption of the sleep-wake cycle
15. Deficiency of perforin secretion
16. Depletion of intracellular magnesium
17. Muscle twitching
18. Mitral valve prolapse
19. Blunting of the HPA axis
20. Sensitivity to stress
21. Panic attacks
22. Hypoglycemia
23. Low blood pressure
24. Low secretory IgA
25. Mitochondrial dysfunction
26. Low VO2 max
27. Hypocapnia
28. Low peripheral body temperature
29. Fatigue and post-exertional exhaustion
30. Weight gain and weight loss
31. Low serum amino acids levels
32. Shortness of breath
33. Weakness
34. Elevated methylmalonate
35. Elevated homocysteine
36. Parasthesia, neuropathy
37. Elevated formiminoglutamate
38. Low WBC
39. Low RBC
40. Elevated MCV and MCH
41. Deficits in synthesis of creatine, choline, carnitine, coenzyme Q10 and melatonin
42. Rise in histamine
43. Neurotransmitter abnormalities
44. Emotional lability
45. Excitotoxicity (anxiety, nervousness, insomnia, sensory sensitization)
46. Myelin disrepair
47. Slow mental processing speed
48. Electromagnetic hypersensitivity
49. Diastolic dysfunction and low cardiac output
50. Diabetes insipidus (polyuria, constant thirst)
51. Low total blood volume
52. Orthostatic hypotension and POTS
53. Loss of temperature regulation
54. Low stomach acid production
55. Slow gastric emptying and GERD
56. Bacterial dysbiosis, yeast infections
57. Irritable bowel syndrome (bloating, abdominal pain, diarrhea, constipation)
58. Leaky gut syndrome
59. Food sensitivities
60. Hashimotos thyroiditis
Best regards,
Rich