I'm on Fredd's protocol and just added SAM-e (200mg) and TMG three days ago. Since then I've been having increased irritability, anxiety and, well, I guess general bleakness. I'm thinking it's one of these supplements since it coincided with their addition and these negative effects seem to be worse in the evening (I take them in the late afternoon).
So I'm wondering if anyone else has had negative effects from SAM-e or TMG?
Thanks!
Hi, Penny.
I think Freddd posted that he is going to be visiting relatives and may not be on the forums as much for a while, so you might not hear from him on this issue. For what it's worth, I'll give you my thoughts on it. If you are on Freddd's protocol at the full dosages he recommends, I think it is likely that your methylation cycle was already being overdriven, so that it was making more SAMe than your body needs, and the excess was being shunted to glycine by the glycine N-methyl transferase reaction, to form sarcosine, which carries the excess methyl groups to the folate metabolism for recycle. Adding additional SAMe directly, or adding TMG, which feeds the BHMT reaction that also raises the production of SAMe, may just be contributing to an overproduction of SAMe that is already present. Because SAMe is important in the metabolism of the neurotransmitters, I think this could explain the symptoms you have experienced.
If you want to check this out, the tests to run are the methylation pathways panel from Health Diagnostics and Research Institute, and the plasma 40-amino acids test offered by Metametrix, which can be obtained from
www.directlabs.com without a doctor's order. These tests will give a picture of what is going on in the methylation cycle and related pathways.
Best regards,
Rich