• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

50% reduction in breast and prostate cancer in people with HIV on antiretrovirals

Bob

Senior Member
Messages
16,455
Location
England (south coast)
Here's an interesting article saying that there is a 50% reduction in the incidence of breast and prostate cancer in people with HIV on antiretroviral therapy.

Letter to the Lancet:

Mouse viruses and human disease
Alexandre FR Stewart, D William Cameron
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext#


Extra info from the article:
"Researchers from several laboratories have identified DNA sequences highly homologous to the mouse mammary tumour virus (MMTV; a betaretrovirus of mice) in about 40% of human breast cancer specimens"


It's interesting that 40% is the same proportion in which they are finding XMRV in prostate cancer patients.
 

Jemal

Senior Member
Messages
1,031
Yep, to me it looks like more evidence mouse retroviruses could be amongst us.
 

Enid

Senior Member
Messages
3,309
Location
UK
Very interesting find Bob - gets one thinking about all the viruses in the "arena" now and antiretroviral benefits.
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
Very interesting find Bob - gets one thinking about all the viruses in the "arena" now and antiretroviral benefits.

Judy now says she has detected the following MLV-related HGRV's:
Friend Virus
spleen focus forming virus
DG-75

And then there's the 'contamination' from GaLV that the CDC found in DeFreitas' samples. GaLV is very similar to MLV's.
(GaLV = gibbon ape leukemia virus.)
Strange how they are now looking for GaLV in monkeys to see if that's where XMRV could have originated.

It does make one wonder!
 

Jemal

Senior Member
Messages
1,031
I am thinking the ride isn't over yet... it has been quite bumpy so far, though :D
 

Enid

Senior Member
Messages
3,309
Location
UK
Reminds me when very ill at 2000 hearing eminent biologists (can't remember which) saying this will be the century of the virus. We would hope faster but looks well on the way.
 

Jemal

Senior Member
Messages
1,031
Yes, I remember those words as well (I tried to Google them yesterday, but found no source). This will be the century of the virus and they are right I think.
 

anciendaze

Senior Member
Messages
1,841
Judy now says she has detected the following MLV-related HGRV's:
Friend Virus
spleen focus forming virus
DG-75

And then there's the 'contamination' from GaLV that the CDC found in DeFreitas' samples. GaLV is very similar to MLV's.
(GaLV = gibbon ape leukemia virus.)
Strange how they are now looking for GaLV in monkeys to see if that's where XMRV could have originated.

It does make one wonder!
There are conflicting reports over that contamination at the CDC: GaLV and MuLV. No source for the contamination was ever traced, yet the CDC developed an exceptionally sensitive test for mouse contamination.
 

currer

Senior Member
Messages
1,409
Which ones? Do you mean the ones that Judy is finding?

Ha! - Yes he would like that!

No - the mouse mammary tumor virus - I dont think that finding got very far at the time, either.

Maybe a lot of people will take courage from the WPI and come out again with their viral findings. I haven't looked into this in detail, but there have been other viral suspects in the past in tumours and they all had problems with reproducability and PCR.
 

liquid sky

Senior Member
Messages
371
Those are pretty significant figures, 50% reduction in breast cancer in those on ARV's and 40% of breast cancer tumors being found by multiple researchers to contain mouse virus fragments.

Sounds like there is a lot to what Judy has been saying about the connection to HGRV's and breast cancer.
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
And then there's this:

Autism Jumps 57% in Just 4 Years
1 in 110 U.S. Kids Has Autism, CDC Study Confirms
Dec. 18, 2009 Autism disorders increased by 57% in just four years, the CDC today reported.
http://www.webmd.com/brain/autism/news/20091218/autism-jumps-57percent-in-just-4-years

This caught my eye particularly because of what Dr Deckoff Jones said in her letter to the Science editors re the WPI's research into autism...

There are more than 1 million ME/CFS patients in the United States alone, 17 million
worldwide. A recently published study found the rate of ASD in South Korean school
children to be 1 in 38 children. We are in the process of demonstrating the clear
association between these two diseases in our patient group. It is an infectious disease.
 

Jemal

Senior Member
Messages
1,031
And then there's this:

Autism Jumps 57% in Just 4 Years
1 in 110 U.S. Kids Has Autism, CDC Study Confirms
Dec. 18, 2009 Autism disorders increased by 57% in just four years, the CDC today reported.
http://www.webmd.com/brain/autism/news/20091218/autism-jumps-57percent-in-just-4-years

This caught my eye particularly because of what Dr Deckoff Jones said in her letter to the Science editors re the WPI's research into autism...

Autism is not an epidemic, they are just developing better diagnostic criteria. At least that's what the government is telling me over here ;)
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
I've just remembered that Dr Singh detected XMRV in 25% of breast cancer tissue samples in a study of 178 samples. This is similar to the detection rate of 23% in her prostate cancer study. I don't think that we've heard much about these results though, so I don't know what's happening with this research.

"The patent application states Dr. Singh has found XMRV in 25% of 178 samples from patients with breast cancer"
http://phoenixrising.me/?p=1923

More info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
http://bodyprinciple.wordpress.com/2010/11/26/dr-singhs-xmrv-patents-now-breast-cancer/
 

redo

Senior Member
Messages
874
Here's an interesting article saying that there is a 50% reduction in the incidence of breast and prostate cancer in people with HIV on antiretroviral therapy.

Letter to the Lancet:

Mouse viruses and human disease
Alexandre FR Stewart, D William Cameron
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext#


Extra info from the article:
"Researchers from several laboratories have identified DNA sequences highly homologous to the mouse mammary tumour virus (MMTV; a betaretrovirus of mice) in about 40% of human breast cancer specimens"


It's interesting that 40% is the same proportion in which they are finding XMRV in prostate cancer patients.

Great find bob! I am too foggy to read now, but the 50% reduction, is that compared to HIV patients not using ARVs, or compared with healthy controls? If it is the latter, than I really think we're onto something.
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
Great find bob! I am too foggy to read now, but the 50% reduction, is that compared to HIV patients not using ARVs, or compared with healthy controls? If it is the latter, than I really think we're onto something.

Good question redo...
I can't be certain because it's not fully explained in the article, but I think it's a comparison to the normal population...
I think the full research is explained in this paper, which I don't have access to:

Spectrum of cancer risk late after AIDS onset in the United States.
Simard EP, Pfeiffer RM, Engels EA.
http://www.ncbi.nlm.nih.gov/sites/e...tern Med[Jour]+AND+170[Volume]+AND+1337[page]
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
Two different retroviruses found in breast cancer.

Dr Singh is reported to have found XMRV in 25% of 178 breast cancers samples.

Other studies have detected retrovirus sequences "highly homologous to the mouse mammary tumour virus (MMTV)" in 40% of breast cancer samples.


The detection rate for MMTV in the breast cancer studies is the same (40%) for some of the studies that detected XMRV in prostate cancer samples (I think - I'm not certain of the details without double-checking). I wonder if this is simply a coincidence.

And I wonder if Judy has detected any MMTV in any of her samples? Except that MMTV is a beta retrovirus, and Judy is looking at gamma retroviruses.

It's very interesting.


---------------------------------------------------

Dr Singh's XMRV results:

"The patent application states Dr. Singh has found XMRV in 25% of 178 samples from patients with breast cancer"
http://phoenixrising.me/?p=1923

More info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
http://bodyprinciple.wordpress.com/2010/11/26/dr-singhs-xmrv-patents-now-breast-cancer/

---------------------------------------------------

MMTV:

Mouse viruses and human disease
Alexandre FR Stewart, D William Cameron
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext#

"Researchers from several laboratories have identified DNA sequences highly homologous to the mouse mammary tumour virus (MMTV; a betaretrovirus of mice) in about 40% of human breast cancer specimens"

----------------------------------------------------
 
Messages
646
but the 50% reduction, is that compared to HIV patients not using ARVs, or compared with healthy controls? If it is the latter, than I really think we're onto something.

http://archinte.ama-assn.org/cgi/content/short/170/15/1337

Arch Intern Med. 2010 Aug 9;170(15):1337-45.

Spectrum of cancer risk late after AIDS onset in the United States.

Simard EP, Pfeiffer RM, Engels EA.


Source

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA.


Abstract

BACKGROUND:

Persons living with AIDS today remain at elevated cancer risk. Highly active antiretroviral therapy (HAART), widely available since 1996, prolongs life, but immune function is not fully restored. We conducted this study to assess long-term cancer risk among persons with AIDS relative to the general population and the impact of HAART on cancer incidence.

METHODS:

Records of 263 254 adults and adolescents with AIDS (1980-2004) from 15 US regions were matched to cancer registries to capture incident cancers during years 3 through 5 and 6 through 10 after AIDS onset. Standardized incidence ratios (SIRs) were used to assess risks relative to the general population. Rate ratios (RRs) were used to compare cancer incidence before and after 1996 to assess the impact of availability of HAART.

RESULTS:

Risk was elevated for the 2 major AIDS-defining cancers: Kaposi sarcoma (SIRs, 5321 and 1347 in years 3-5 and 6-10, respectively) and non-Hodgkin lymphoma (SIRs, 32 and 15). Incidence of both malignancies declined in the HAART era (1996-2006). Risk was elevated for all non-AIDS-defining cancers combined (SIRs, 1.7 and 1.6 in years 3-5 and 6-10, respectively) and for the following specific non-AIDS-defining cancers: Hodgkin lymphoma and cancers of the oral cavity and/or pharynx, tongue, anus, liver, larynx, lung and/or bronchus, and penis. Anal cancer incidence increased between 1990-1995 and 1996-2006 (RR, 2.9; 95% confidence interval [CI], 2.1-4.0), as did that of Hodgkin lymphoma (RR, 2.0; 95% CI, 1.3-2.9).

CONCLUSION:

Among people who survived for several years or more after an AIDS diagnosis, we observed high risks of AIDS-defining cancers and increasing incidence of anal cancer and Hodgkin lymphoma.

The key thing to know would be the age profile of the two study populations , but there are numerous confounding factors and while a 50% reduction is signficant, the total occurrences of breast and prostate cancers in the two populations may actually be quite small.

IVI