Wow - great find Cort. I was just researching into LDN and it looks v hopeful. V interesting also re the effect on the microglia - makes sense.
Re the insomnia effects - I understand that the timing of taking it is all important.
An ME patient posted on YouTube recently about this stimulant effect saying that she finds it works better taken once you are in bed & literally as you are turning the light out (NOT a couple of hours before.) ie this means that the effects will kick in a couple of hours later
as you are asleep, not beforehand when you are trying to get to sleep.
She also mentioned that the difference between the 3mgs dose and a 4.5mgs dose for an ME patient can make all the difference between the drug being effective for someone, or having to stop it due to overstimulation (ie 3 mgs might be less stimulating and more effective therefore, but everyone is different).
Amazing when you realise that the regular dose for other illnesses is a 50 mg tablet/capsule! LDN capsules for ME patients have to be prepared especially by a responsible pharmacist (because they aren't commercially manufactured at these incredibly low doses), and it is important to insist on the version of the drug that is NOT time delayed for release.
If I understood correctly, I think LDN acts by suppressing Serotonin initially, causing a reactive surge in the body subsequently, which 're calibrates' nervous system, or resets/ kick starts immune system and gives you a nice feeling!
Apparently there is a big UK patient movement trying to get government funding for drug trials for this low dose LDN as it is so effective in many autoimmune conditions, but not commercially viable for drug companies to fund expensive trials. Usual dilemma about expired patients/generic drugs etc I think.
Haven't viewed video above yet, so apologies if repeating anything obvious.